Aminopeptidase A inhibitors as centrally acting antihypertensive agents

Autor: Yannick Marc, Catherine Llorens-Cortes, Laurence Bodineau, Cédric Claperon, Alain Frugière
Přispěvatelé: Neuropeptides centraux et régulations hydrique et cardiovasculaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre interdisciplinaire de recherche en biologie (CIRB), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Llorens Cortes, Catherine
Jazyk: angličtina
Rok vydání: 2008
Předmět:
medicine.medical_specialty
Angiotensin III
030204 cardiovascular system & hematology
Pharmacology
Glutamyl Aminopeptidase
Models
Biological
MESH: Hypertension
Renin-Angiotensin System
03 medical and health sciences
0302 clinical medicine
Aminopeptidase A
In vivo
MESH: Renin-Angiotensin System
Internal medicine
Renin–angiotensin system
medicine
Animals
MESH: Animals
MESH: Disulfides
Disulfides
Enzyme Inhibitors
Receptor
Antihypertensive Agents
030304 developmental biology
[SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
chemistry.chemical_classification
MESH: Glutamyl Aminopeptidase
0303 health sciences
MESH: Antihypertensive Agents
Effector
business.industry
Angiotensin II
MESH: Models
Biological
MESH: Angiotensin III
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
3. Good health
Endocrinology
Blood pressure
Enzyme
chemistry
MESH: Enzyme Inhibitors
Hypertension
MESH: Sulfonic Acids
MESH: Angiotensin II
Sulfonic Acids
Cardiology and Cardiovascular Medicine
business
Zdroj: Heart Failure Reviews
Heart Failure Reviews, Springer Verlag, 2008, 13 (3), pp.311-9. ⟨10.1007/s10741-007-9077-3⟩
Heart Failure Reviews, 2008, 13 (3), pp.311-9. ⟨10.1007/s10741-007-9077-3⟩
ISSN: 1382-4147
1573-7322
DOI: 10.1007/s10741-007-9077-3⟩
Popis: International audience; Among the main bioactive peptides of the brain renin-angiotensin system, angiotensin (Ang) II and AngIII exhibit the same affinity for the type 1 and type 2 Ang receptors. Both peptides, injected intracerebroventricularly, cause similar increase in blood pressure (BP). Because AngII is converted in vivo to AngIII, the identity of the true effector is unknown. This review summarized recent insights into the predominant role of brain AngIII in the central control of BP underlining the fact that brain aminopeptidase A (APA), the enzyme forming central AngIII, could constitute a putative central therapeutic target for the treatment of hypertension. This led to the development of potent, systematically active APA inhibitors, such as RB150, as a prototype of a new class of centrally acting antihypertensive agents for the treatment of certain forms of hypertension.
Databáze: OpenAIRE
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