Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood
| Autor: | Christopher Käufer, Julie Sellau, Fabio Morellini, Stephanie Jansen, Ralf Bartenschlager, Ursula Müller, Melanie Richter, Lynn Schau, Robin Scharrenberg, Annette Preuß, Jonas Schmidt-Chanasit, Wolfgang Löscher, Stephanie Stanelle-Bertram, Helmut Fuchs, Sabine M. Hölter, Petra C. Arck, Oana V. Amarie, Vanessa Herder, Gülsah Gabriel, Vanessa M. Pfankuche, Carola Dreier, Froylan Calderon de Anda, Hanna Lotter, Ingo Gerhauser, Vanessa Kraus, Kerstin Walendy-Gnirß, Ronja Dörk, Gundula Pilnitz-Stolze, Olli Vapalahti, Martin Gabriel, Thais Moraes, Sany Benites, Stefan Hoenow, Daniel Cadar, Harald Ittrich, Benjamin Schattling, Swantje Thiele, Lane Rolling, Ivy Asantewaa Asante, Udo Bartsch, Stefanie Thanisch, Manuel A. Friese, Inken Waltl, Thomas Speiseder, Martin Hrabé de Angelis, Thomas Renné, Nancy Mounogou Kouassi, Wolfgang Baumgärtner |
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| Přispěvatelé: | Medicum, Veterinary Microbiology and Epidemiology, Veterinary Biosciences, Olli Pekka Vapalahti / Principal Investigator, Viral Zoonosis Research Unit, Department of Virology, University of Helsinki, Clinicum |
| Jazyk: | němčina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Physiology Morris water navigation task Applied Microbiology and Biotechnology Zika virus Pregnancy Testosterone Pregnancy Complications Infectious biology Learning Disabilities Zika Virus Infection Brain 3. Good health MORRIS WATER MAZE LEADS In utero GROWTH Female Microbiology (medical) Offspring Birth weight MODELS Immunology Neurocognitive Disorders VIRUS-INFECTION Microbiology 03 medical and health sciences Sex Factors Genetics medicine Animals Humans EXPOSURE Fetus business.industry MEMORY Zika Virus Cell Biology Placental Insufficiency biology.organism_classification medicine.disease Infectious Disease Transmission Vertical Disease Models Animal 030104 developmental biology Animals Newborn 3111 Biomedicine business Neurocognitive |
| Zdroj: | Nat. Microbiol. 3, 1161–1174 (2018) |
| Popis: | Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in -1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious phenotypes. Male offspring born to LD ZIKV-infected mothers had increased testosterone (TST) levels and were less likely to survive in utero infection compared to their female littermates. Males also presented an increased number of immature neurons in apical and basal hippocampal dendrites, while female offspring had immature neurons in basal dendrites only. Moreover, male offspring with high but not very high (storm) TST levels were more likely to suffer from learning and memory impairments compared to females. Future studies are required to understand the impact of TST on neuropathological and neurocognitive impairments in later life. In summary, increased sex-specific vigilance is required in countries with high ZIKV prevalence, where impaired neurodevelopment may be camouflaged by a healthy appearance at birth. |
| Databáze: | OpenAIRE |
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