Study on Cathepsin B Activity in Human Thyroid Tumors
| Autor: | Kunihiko Funasaka, Kiyotaka Murata, Takayuki Nakano, Shozo Nishida, Takanori Tomura, Takeshi Kusunoki, Saori Kimoto |
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| Rok vydání: | 1995 |
| Předmět: |
Adenoma
endocrine system Pathology medicine.medical_specialty endocrine system diseases Thyroid Gland Cathepsin B Metastasis Thyroid carcinoma Type IV collagen Adenocarcinoma Follicular Follicular phase Biomarkers Tumor medicine Humans Neoplasm Invasiveness Collagenases Thyroid Neoplasms Cathepsin S business.industry General Medicine Prognosis medicine.disease Carcinoma Papillary Graves Disease Otorhinolaryngology Cathepsin B activity Lymphatic Metastasis Surgery Collagen business |
| Zdroj: | Auris Nasus Larynx. 22:43-48 |
| ISSN: | 0385-8146 |
| DOI: | 10.1016/s0385-8146(12)80181-7 |
| Popis: | Cathepsin B activity was measured in human thyroid tissue obtained surgically from 2 patients with Grave's disease, 3 with follicular adenoma, 4 with papillary carcinoma, and 4 with follicular carcinoma. Three normal thyroid tissues were also studied. Comparisons were made between cathepsin B activity and clinical findings, including histopathological diagnosis and the presence or absence of extra-capsular invasion and metastasis. The abilities of original tumors to degrade type I and type IV collagen were also measured. Mean cathepsin B activities of both specimens with benign and those with malignant disease were significantly higher than those of normal thyroid. On cases of thyroid carcinoma, those with extra-capsular invasions and metastasis had the highest cathepsin B activities. Cases with high cathepsin B activities also tended to show high type I and IV collagen degrading abilities. These findings suggest that cathepsin B plays a role in the development of extra-capsular invasion and lymph node metastasis in human thyroid tumors. |
| Databáze: | OpenAIRE |
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