Homotypic and heterotypic serum and milk antibody to rotavirus in normal, infected and vaccinated horses
| Autor: | T. A. Fitzgerald, C.S.H. Sale, D. R. Snodgrass, Rachel M. Chalmers, Glenn F. Browning |
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| Rok vydání: | 1991 |
| Předmět: |
Serotype
Rotavirus endocrine system animal diseases Reoviridae Enzyme-Linked Immunosorbent Assay Biology Cross Reactions medicine.disease_cause Antibodies Viral Microbiology Rotavirus Infections Article Epitopes Immune system fluids and secretions Species Specificity medicine Animals Horses Serotyping General Veterinary Vaccination Horse virus diseases Antibodies Monoclonal Viral Vaccines General Medicine biology.organism_classification Virology Immunoglobulin A Milk Immunoglobulin G Humoral immunity Immunology biology.protein Female Horse Diseases Antibody |
| Zdroj: | Veterinary Microbiology Scopus-Elsevier |
| ISSN: | 0378-1135 |
| Popis: | The homotypic and heterotypic antibody response to rotavirus was determined in three pony mares and their foals. The normal concentrations of anti-rotavirus antibodies in mares ‘milk and mares’ and foals′ serum over the first 10 weeks post-partum were measured using IgA, IgG and rotavirus sero-type-specific enzyme linked immunosorbent assays. Experimental infection of the foals with serotype 3 equine rotavirus produced a rapid, serotype-specific response which peaked 10 days after infection and a slower heterotypic response which peaked 32 days later. In contrast, vaccination of the mares with an inactivated, adjuvanted serotype 6 bovine rotavirus produced a heterotypic response similar to that of the homotypic response in both serum and milk, although the predominant response in serum was IgG, while in milk it was IgA. These results suggest that non serotype-restricted passive protection of foals against rotavirus may be achieved by parenteral vaccination of mares. |
| Databáze: | OpenAIRE |
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