Alteration of Ceramide 1-O-Functionalization as a Promising Approach for Cancer Therapy
| Autor: | Stéphanie Ballereau, Thierry Levade, Nathalie Andrieu-Abadie, Yves Genisson |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Ceramide Transferases (Other Substituted Phosphate Groups) Apoptosis Context (language use) Biology Ceramides chemistry.chemical_compound Neoplasms Ceramide kinase Sphingomyelin synthase medicine Animals Humans Enzyme Inhibitors Pharmacology Cancer medicine.disease Sphingolipid Cell biology Phosphotransferases (Alcohol Group Acceptor) chemistry Glucosyltransferases Cancer cell biology.protein Molecular Medicine Sphingomyelin |
| Zdroj: | ResearcherID |
| ISSN: | 1871-5206 |
| DOI: | 10.2174/187152012800228634 |
| Popis: | Sphingolipids, which are complex lipidic components of the cell membranes, lie in a key position to modulate the pathways of trans-membrane signaling and allow the cell to adapt to environmental stresses. In malignancies, reduced production of some sphingolipid species able to induce apoptosis such as ceramide and conversely, increased levels of some other metabolites involved in tumor progression and drug resistance of cancer cells, are often described. In this context, the discovery of new chemical entities able to specifically modify ceramide metabolism should offer novel pharmacological tools in cancer therapy. The review dedicates particular attention to the enzymes that modify ceramide at the C1-OH position generating other biologically important sphingolipids in cancer, such as sphingomyelin, ceramide-1-phosphate or glucosylceramide. Findings reported in the literature leading to the development of new chemical entities specifically designed to achieve the above goals have been collected and are discussed. The effects of enzyme inhibitors of sphingomyelin synthase, ceramide kinase and glucosylceramide synthase on cancer cell proliferation, sensitivity to chemotherapeutics, induction of apoptosis or growth of xenografts are presented. |
| Databáze: | OpenAIRE |
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