Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells
| Autor: | F. Grimminger, Trinad Chakraborty, Werner Seeger, Frank Rose, Ulf Sibelius, Juergen Wehland, S. Weiss, Ayub Darji |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Bacterial Toxins
Immunology Biology Phosphatidylinositols Microbiology Umbilical vein Hemolysin Proteins chemistry.chemical_compound Humans Secretion Phosphatidylinositol Platelet Activating Factor Cells Cultured Heat-Shock Proteins L-Lactate Dehydrogenase Platelet-activating factor Listeriolysin O Lipid signaling Epoprostenol Cell biology Endothelial stem cell Infectious Diseases chemistry Biochemistry Parasitology Human umbilical vein endothelial cell Endothelium Vascular Research Article |
| Zdroj: | Infection and Immunity. 64:674-676 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.64.2.674-676.1996 |
| Popis: | The impact of Listeria monocytogenes listeriolysin O (LLO) secretion on phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LLO production were ineffective. Thus, human umbilical vein endothelial cell stimulation by listeriae is linked to production of LLO. |
| Databáze: | OpenAIRE |
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