Anastatin Derivatives Alleviate Myocardial Ischemia-Reperfusion Injury via Antioxidative Properties
| Autor: | Weida Zheng, Lianbo Zhao, Chaoran Yao, Fu Ying, Peng Yu, Yuou Teng, Rengui Saxu, Zhao Cai |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Antioxidant Myocardial ischemia Cell Survival medicine.medical_treatment Pharmaceutical Science Organic chemistry Apoptosis Myocardial Reperfusion Injury cardioprotective effects Pharmacology Antioxidants Article Analytical Chemistry Superoxide dismutase chemistry.chemical_compound QD241-441 In vivo Malondialdehyde Drug Discovery medicine Animals Physical and Theoretical Chemistry Flavonoids biology Chemistry Glutathione medicine.disease In vitro Rats Oxidative Stress H9c2 cells Chemistry (miscellaneous) flavonoids derivatives biology.protein Molecular Medicine Creatine kinase hypoxia/reoxygenation Reperfusion injury |
| Zdroj: | Molecules, Vol 26, Iss 4779, p 4779 (2021) Molecules Volume 26 Issue 16 |
| ISSN: | 1420-3049 |
| Popis: | (±)-Anastatins A and B are flavonoids isolated from Anastatica hierochuntica. In a previous study, twenty-four di- and tri-substituted novel derivatives of anastatins were designed and their preliminary antioxidant activities were evaluated. In the present study, the protective effect of myocardial ischemia-reperfusion (I/R) and the systematic antioxidant capacity of 24 derivatives were further studied. Compound 13 was the most potent among all the compounds studied, which increased the survival of H9c2 cells to 80.82%. The antioxidant capability of compound 13 was evaluated in ferric reducing antioxidant power, 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging, and 2,2-diphenyl-1-picrylhydrazyl assays. It was observed that compound 13 significantly reduced infarcted areas and improved histopathological and electrocardiogram changes in rats with myocardial I/R injury. Moreover, compound 13 decreased the leakage rates of serum lactate dehydrogenase, creatine kinase, and malonyldialdehyde from rat myocardial tissues and increased the level of glutathione and superoxide dismutase activities following myocardial I/R injury in rats. Taken together, we concluded that compound 13 had potent cardioprotective effects against myocardial I/R injury both in vitro and in vivo owing to its extensive antioxidant activities. |
| Databáze: | OpenAIRE |
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