Differential efficacy of non-invasive vagus nerve stimulation for the acute treatment of episodic and chronic cluster headache: A meta-analysis

Autor:	Stephen D. Silberstein, Juana Marin, Peter J. Goadsby, Candace McClure, Ilse F. de Coo, Deborah I. Friedman, Eric Liebler, Stewart J. Tepper, Alok Tyagi, Michel D. Ferrari, Charly Gaul
Rok vydání:	2019
Předmět:	chronic cluster headache non-invasive vagus nerve stimulation business.industry Cluster headache medicine.medical_treatment Non invasive acute treatment General Medicine medicine.disease Neuromodulation (medicine) 3. Good health meta-analysis 03 medical and health sciences 0302 clinical medicine Episodic cluster headache Meta-analysis Anesthesia neuromodulation medicine 030212 general & internal medicine Neurology (clinical) business 030217 neurology & neurosurgery Vagus nerve stimulation
Zdroj:	Cephalalgia, 39(8), 967-977
ISSN:	1468-2982 0333-1024
DOI:	10.1177/0333102419856607
Popis:	Background Two randomized, double-blind, sham-controlled trials (ACT1, ACT2) evaluated non-invasive vagus nerve stimulation (nVNS) as acute treatment for cluster headache. We analyzed pooled ACT1/ACT2 data to increase statistical power and gain insight into the differential efficacy of nVNS in episodic and chronic cluster headache. Methods Data extracted from ACT1 and ACT2 were pooled using a fixed-effects model. Main outcome measures were the primary endpoints of each study. This was the proportion of participants whose first treated attack improved from moderate (2), severe (3), or very severe (4) pain intensity to mild (1) or nil (0) for ACT1 and the proportion of treated attacks whose pain intensity improved from 2–4 to 0 for ACT2. Results The pooled population included 225 participants (episodic: n = 112; chronic: n = 113) from ACT1 (n = 133) and ACT2 (n = 92) in the nVNS (n = 108) and sham (n = 117) groups. Interaction was shown between treatment group and cluster headache subtype ( p Conclusions nVNS is a well-tolerated and effective acute treatment for episodic cluster headache. Trial registration The studies were registered at clinicaltrials.gov (ACT1: NCT01792817; ACT2: NCT01958125).
Databáze:	OpenAIRE
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