beta-Adrenoceptor blocking effects and pharmacokinetics of pindolol. A study in hypertensive Africans
| Autor: | A. Ragon, A. O. Falase, Risquat A. Adio, L. A. Salako |
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| Rok vydání: | 1979 |
| Předmět: |
Tachycardia
Adult Male medicine.medical_specialty Time Factors genetic structures Adrenergic beta-Antagonists Physical Exertion Blood Pressure Pharmacology Placebo Placebos Pharmacokinetics Double-Blind Method Oral administration Internal medicine Heart rate polycyclic compounds medicine Humans Pharmacology (medical) Pindolol business.industry organic chemicals General Medicine Beta adrenoceptor Middle Aged Kinetics Blood pressure Hypertension cardiovascular system Cardiology Female medicine.symptom business circulatory and respiratory physiology medicine.drug Half-Life |
| Zdroj: | European journal of clinical pharmacology. 15(5) |
| ISSN: | 0031-6970 |
| Popis: | The beta-adrenoceptor blocking effects of pindolol were compared with those of a placebo in a double-blind trial in twelve hypertensive Africans. Heart rate and arterial blood pressure were measured at rest and immediately after exercise, before and at intervals up to 8 h after oral administration of the drugs. Plasma levels of pindolol were also determined. Pindolol reduced systolic blood pressure and antagonised exercised-induced tachycardia. The mean time to peak level of pindolol was 1.9 h and the mean half-life was 4.2 h. Comparison of plasma levels of pindolol and beta-adrenoceptor blocking activity showed good correlation between them. It is concluded that the pharmacokinetics and beta-blocking effects of pindolol in Africans are not dissimilar from published data for other races. |
| Databáze: | OpenAIRE |
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