Quality control of hemoglobin-based blood substitutes
| Autor: | Er Ss, Hsia Jc |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Quality Control
Commercial scale Chemical Phenomena Chemistry media_common.quotation_subject Plasma Substitutes Ultrafiltration General Medicine Diphosphoglyceric Acids Blood substitute Solutions Hemoglobins Adenosine Triphosphate Blood Substitutes Volume expansion Pyridoxal Phosphate Oxygen delivery Quality (business) Hemoglobin Chromatography High Pressure Liquid media_common Biomedical engineering |
| Zdroj: | Biomaterials, artificial cells, and artificial organs. 16(1-3) |
| ISSN: | 0890-5533 |
| Popis: | Preparation and use of hemoglobin-based blood substitutes, from stroma-free hemoglobin (SFH or Hb) and its DPG analogue-modified derivatives (PLP-Hb, ATP-Hb etc.) without thorough characterization and quality control in animal or human testing have produced, and may continue to produce, artifacts in the finished product. Thus the development of such a natural substitute for the volume expansion and oxygen delivery functions of the blood will be impeded. A case is made for the use of affinity purified hemoglobin and modified hemoglobin as standard starting materials for the preparation of Hb-based blood substitute(s) in general, and in particular poly PLP-Hb. Development of a commercial scale blood-substitute is only possible after the safety and toxicity issues of substitutes have been resolved by applying rigorous quality control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|