Prenatal and early postnatal phthalate exposure and child neurodevelopment at age of 7 years - Polish Mother and Child Cohort
| Autor: | Kinga Polańska, Wojciech Hanke, Danuta Ligocka, Małgorzata Waszkowska, Aleksander Stańczak, Anna Maria Tartaglione, Gemma Calamandrei, Mercè Garí, Agnieszka Jankowska, Flavia Chiarotti, Fiorino Mirabella, Ewelina Wesołowska |
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| Rok vydání: | 2019 |
| Předmět: |
Phthalic Acids
Mothers 010501 environmental sciences 01 natural sciences Biochemistry Cohort Studies 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Child Development Pregnancy Medicine Humans 030212 general & internal medicine Early childhood Child 0105 earth and related environmental sciences General Environmental Science Psychomotor learning business.industry Phthalate Neuropsychology Strengths and Difficulties Questionnaire Environmental Exposure medicine.disease chemistry Child Preschool Cohort Environmental Pollutants Female Poland business Clinical psychology Cohort study |
| Zdroj: | Environmental research. 177 |
| ISSN: | 1096-0953 |
| Popis: | Phthalates are among the most frequently investigated environmental chemicals influencing children's health and particularly their neuropsychological development. However, the reported effects of these compounds on child behavior, cognitive and psychomotor outcomes are not fully consistent. The aim of this study is to evaluate the associations between prenatal and early postnatal phthalate exposures and child neurodevelopment at age of 7 years. A total of 134 mother-child pairs from Polish Mother and Child Cohort (REPRO_PL) constitute the basis for current analysis. Eleven phthalate metabolites were measured in urine samples collected from mothers in the 3rd trimester of pregnancy and from children at the age of 2 years. Child neuropsychological development at early school age (7 years) was assessed by both the Strengths and Difficulties Questionnaire (SDQ) filled by mothers and the Polish adaptation of the Intelligence and Development Scales (IDS) performed by psychologists. Mono-ethyl phthalate (MEP) concentration during pregnancy was significantly associated with increased risk of peer relationship problems in SDQ (OR = 2.7, p = 0.03). The results of the IDS analyses focused on child's cognitive and psychomotor development are not fully conclusive. Negative associations were evident between some phthalates in early childhood period and fluid intelligence and cognition (MEP: β = −5.2; p = 0.006; β = −4.2; p = 0.006; mono-n-butyl phthalate (MnBP): β = −4.9; p = 0.03; β = −4.0; p = 0.03; respectively), while positive associations have been found in the prenatal period (mono-2-ethyl-5-oxo-hexyl phthalate (oxo-MEHP): β = 3.6; p = 0.03 for fluid intelligence; β = 2.9; p = 0.03 for cognition). Further studies are required in order to elucidate which are the most critical periods of phthalate exposure on children's neurodevelopmental outcomes. |
| Databáze: | OpenAIRE |
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