Pleomorphic Malignant Mesothelioma in a Broiler Breeder Infected with Avian Leucosis Virus Subgroup J
| Autor: | Tomoaki Murakami, Yukiko Sassa |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Mesothelioma
0301 basic medicine Pathology medicine.medical_specialty Lung Neoplasms Myeloid 040301 veterinary sciences Vimentin Virus Pathology and Forensic Medicine Leucosis 0403 veterinary science 03 medical and health sciences Cytokeratin Lymphoid Leucosis medicine Animals Poultry Diseases Avian Leukosis Virus General Veterinary biology Mesothelioma Malignant 04 agricultural and veterinary sciences medicine.disease 030104 developmental biology medicine.anatomical_structure Avian Leukosis biology.protein Immunohistochemistry Female Chickens |
| Zdroj: | Journal of Comparative Pathology. 160:50-55 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/j.jcpa.2018.03.003 |
| Popis: | Summary Avian leucosis virus (ALV) is an oncogenic retrovirus that induces tumours including lymphoid leucosis and myeloid leucosis. Pleomorphic malignant mesothelioma and myelocytoma, which were thought to be induced by ALV subgroup J (ALV-J) infection, were identified in a 432-day-old broiler breeder. The bird showed no clinical signs; however, at necropsy examination there were multiple nodules in the alimentary tract. Microscopical analysis showed that these consisted of pleomorphic cells and myelocyte-like cells. Immunohistochemistry revealed that the pleomorphic cells were atypical and expressed cytokeratin, vimentin, c-kit, calretinin and ALV. The myelocyte-like cells were also positive for ALV. Retroviral type C particles were observed by electron microscopy. ALV-E and ALV-J nucleotide sequences were detected in DNA extracted from formalin-fixed and paraffin wax-embedded small intestinal tissue. Based on these results, the tumours were diagnosed as pleomorphic malignant mesothelioma and myelocytoma and were thought to have been induced by ALV-J infection. This is the first report of malignant mesothelioma associated with naturally acquired ALV-J infection. |
| Databáze: | OpenAIRE |
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