Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome
| Autor: | Kai Meng, Yujie Zhou, Bangwei Wu, Qiutang Zeng, Ying Huang, Meng Chai, Ying Shi, Yingzhong Lin, Qingwei Ji, Zhengde Lu, Yuyang Liu, Kunwu Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Article Subject medicine.drug_class Immunology Myocardial Infarction Enzyme-Linked Immunosorbent Assay Coronary Angiography Ventricular Function Left Angina Pectoris Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide lcsh:Pathology Humans Myocardial infarction cardiovascular diseases Acute Coronary Syndrome Aged Ejection fraction biology Unstable angina business.industry C-reactive protein Interleukin-18 Interleukin Cell Biology Middle Aged medicine.disease Echocardiography Doppler Peptide Fragments C-Reactive Protein Acute Disease biology.protein Cardiology Leukocytes Mononuclear Intercellular Signaling Peptides and Proteins Interleukin 18 Female business lcsh:RB1-214 Research Article Interleukin-1 |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2014 (2014) |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Objective.More recently, evidence showed that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases. However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated.Methods.Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients.Results.The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients. A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP),N-terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF). Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis.Conclusions.The results indicate that the plasma IL-37 levels are associated with the onset of ACS. |
| Databáze: | OpenAIRE |
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