Zidovudine absorption and small intestinal function in HIV seropositive patients
| Autor: | K A, Macnab, M J, Gill, L R, Sutherland, A, Murphy, R, Brant |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Diarrhea Male Microbiology (medical) medicine.medical_specialty Loperamide medicine.medical_treatment Administration Oral Antiviral Agents Gastroenterology Lactulose Zidovudine Pharmacokinetics Oral administration Internal medicine HIV Seropositivity Intestine Small medicine Humans Pharmacology (medical) Prospective Studies Sida Pharmacology Chemotherapy biology business.industry digestive oral and skin physiology Middle Aged biology.organism_classification Infectious Diseases Intestinal Absorption Immunology medicine.symptom business medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 37:825-829 |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | Zidovudine absorption was evaluated in HIV seropositive patients with (n = 15) and without diarrhoea (n = 20) in a standardised prospective pharmacokinetic study using single oral 200 mg doses. Zidovudine was rapidly absorbed with large peak variation (Cmax: 1.10 +/- 0.43 mg/L). There were no significant associations between pharmacokinetic parameters and presence of diarrhoea, CD4 counts, red blood cell folate concentrations, stool cultures/leucocytes or the lactulose/mannitol absorption test. Mean diarrhoea AUC (mg/L.h) was 1.13 +/- 0.30 and 1.07 +/- 0.36 in non-diarrhoeal patients. Antidiarrhoeals increased AUC and Cmax values in a small, non statistically significant subset of diarrhoea patients. Although zidovudine absorption varies significantly, our data do not support dosage individualisation based on any of the above parameters. |
| Databáze: | OpenAIRE |
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