The clinical spectrum of childhood narcolepsy
| Autor: | Yves Dauvilliers, Elena Antelmi, Fabio Pizza, Emanuela Postiglione, Michel Lecendreux, Giuseppe Plazzi |
|---|---|
| Přispěvatelé: | Hôpital Robert Debré, Département de neurologie [Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Postiglione, Emanuela, Antelmi, Elena, Pizza, Fabio, Lecendreux, Michel, Dauvilliers, Yve, Plazzi, Giuseppe, Hôpital Gui de Chauliac [Montpellier]-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Université de Montpellier (UM), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Neurology Cataplexy Polysomnography Excessive daytime sleepiness Weight Gain Movement disorder Narcolepsy Obesity Precocious puberty Treatment Neurology (clinical) Physiology (medical) Irritability 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Child Psychiatry medicine.disease Hypotonia 3. Good health Mood [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] medicine.symptom Psychology Sleep paralysis [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology 030217 neurology & neurosurgery |
| Zdroj: | Sleep Medicine Reviews Sleep Medicine Reviews, Elsevier, 2018, 38, pp.70-85. ⟨10.1016/j.smrv.2017.04.003⟩ |
| ISSN: | 1087-0792 |
| DOI: | 10.1016/j.smrv.2017.04.003 |
| Popis: | International audience; Narcolepsy type 1 is a life-long, severe, multifaceted disease often arising in childhood or adolescence. Beyond the classical symptoms (excessive daytime sleepiness, cataplexy, hallucinations, sleep paralysis and nocturnal fragmented sleep), metabolic, endocrinological, psychiatric and psychosocial aspects must be considered. Despite the increased awareness after H1N1 pandemic influenza and vaccination, narcolepsy is still misdiagnosed and unrecognized. The peculiar presentation of symptoms in narcoleptic children could in part explain the misdiagnoses. Excessive daytime sleepiness presenting as chronic drowsiness or irritability could be stigmatized as laziness or misinterpreted as behavior or inattention disorder. The persistent hypotonia and the complex hyperkinetic movements that characterize cataplexy close to the onset, could be misdiagnosed as a movement disorder or as other neurologic conditions. The consequent therapeutic delay could turn into dramatic consequences. The narcolepsy onset, indeed, is associated with abrupt weight gain and sometimes with precocious puberty that require a prompt recognition and treatment to avoid auxological and metabolic complications. Moreover, narcoleptic children could have behavioral and psychiatric disorders ranging from mood to psychotic ones that need ad hoc management. Accordingly, spreading the awareness outside the sleep specialist community is necessary in order to reduce the diagnostic delay and to obtain prompt and multidisciplinary management. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect