Potent Antimicrobial Activity of Lipidated Short α,γ-Hybrid Peptides
| Autor: | Sushil N. Benke, Hirekodathakallu V. Thulasiram, Hosahudya N. Gopi |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Gram-negative bacteria Erythrocytes medicine.drug_class Antibiotics Microbial Sensitivity Tests 010402 general chemistry Gram-Positive Bacteria 01 natural sciences Biochemistry Hemolysis Bacterial cell structure Microbiology 03 medical and health sciences chemistry.chemical_compound Lipopeptides Anti-Infective Agents Drug Discovery Gram-Negative Bacteria medicine Cationic Lipopeptides Humans Amino Acid Sequence General Pharmacology Toxicology and Pharmaceutics Mode of action Pharmacology biology Organic Chemistry Lipopeptide Antimicrobial biology.organism_classification 0104 chemical sciences 030104 developmental biology Mechanism of action chemistry Microscopy Electron Scanning Molecular Medicine medicine.symptom |
| Zdroj: | ChemMedChem. 12(19) |
| ISSN: | 1860-7187 |
| Popis: | We are reporting potent antimicrobial activity of alpha,gamma-hybrid lipopeptides constituted with 1:1 alternating alpha- and gamma-amino acids. Along with their potent antimicrobial activity against various Gram positive and Gram negative bacteria, these hybrid lipopeptides were found to be less haemolytic. The mechanism of action revealed that these short cationic lipopeptides bind and disrupt the bacterial cell membrane. Further, the time kill kinetics analysis revealed that the potent alpha,gamma-hybrid lipopeptides completely inhibit the bacterial growth in less than 20 minutes. Overall, the promising antimicrobial activity along with less haemolytic activity displayed by the alpha,gamma-hybrid lipopeptides can be further explored to design potent lipopeptide antibiotics. |
| Databáze: | OpenAIRE |
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