Taï Forest Virus Does Not Cause Lethal Disease in Ferrets
| Autor: | Huajun Zhang, Shihua He, Kevin Tierney, Karla Emeterio, Xiangguo Qiu, Wenjun Zhu, Zachary Schiffman, Logan Banadyga, Feihu Yan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
filovirus
0301 basic medicine Microbiology (medical) viruses 030106 microbiology Disease Biology medicine.disease_cause Microbiology Article Virus Viral hemorrhagic fever Pathogenesis 03 medical and health sciences Immune system Virology medicine viral hemorrhagic fever ferret lcsh:QH301-705.5 ebolavirus Ebolavirus Ebola virus animal model pathogenesis medicine.disease Côte d’Ivoire ebolavirus Titer 030104 developmental biology lcsh:Biology (General) Taï Forest virus TAFV |
| Zdroj: | Microorganisms, Vol 9, Iss 213, p 213 (2021) Microorganisms Volume 9 Issue 2 |
| ISSN: | 2076-2607 |
| DOI: | 10.3390/microorganisms9020213 |
| Popis: | Filoviruses are zoonotic, negative-sense RNA viruses, most of which are capable of causing severe disease in humans and nonhuman primates, often with high case fatality rates. Among these viruses, those belonging to the Ebolavirus genus&mdash particularly Ebola virus, Sudan virus, and Bundibugyo virus&mdash represent some of the most pathogenic to humans. Taï Forest virus (TAFV) is thought to be among the least pathogenic ebolaviruses however, only a single non-fatal case has been documented in humans, in 1994. With the recent success of the ferret as a lethal model for a number of ebolaviruses, we set out to evaluate its suitability as a model for TAFV. Our results demonstrate that, unlike other ebolaviruses, TAFV infection in ferrets does not result in lethal disease. None of the intramuscularly inoculated animals demonstrated any overt signs of disease, whereas the intranasally inoculated animals exhibited mild to moderate weight loss during the early stage of infection but recovered quickly. Low levels of viral RNA were detected in the blood and tissues of several animals, particularly the intranasally inoculated animals, and all animals mounted a humoral immune response, with high titers of GP-specific IgG detectable as early as 14 days post-infection. These data provide additional insight into the pathogenesis of TAFV. |
| Databáze: | OpenAIRE |
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