The Metabolism of [14C]β-Carotene and the Presence of Other Carotenoids in Rats and Monkeys
| Autor: | Niels C. G. Lausen, Sudha Welankiwar, Prabhat K. Sehgal, Norman I. Krinsky, M D Russett, Micheline M. Mathews-Roth |
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| Rok vydání: | 1990 |
| Předmět: |
Vitamin
Lutein medicine.medical_specialty Time Factors medicine.medical_treatment Medicine (miscellaneous) Biology Absorption chemistry.chemical_compound Oral administration beta-Carotene Internal medicine medicine Animals Vitamin D Vitamin A Carotenoid chemistry.chemical_classification Nutrition and Dietetics Carotene Retinol Rats Inbred Strains beta Carotene Carotenoids Macaca mulatta Diet Rats Zeaxanthin Endocrinology Liver chemistry Organ Specificity Female |
| Zdroj: | The Journal of Nutrition. 120:81-87 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/120.1.81 |
| Popis: | The metabolism of beta-carotene has been studied in both rats and Rhesus monkeys, following the oral administration of [14C]beta-carotene in olive oil supplemented with 1 mg/mL alpha-tocopherol. In the rats, peak serum accumulation of [14C]retinol occurred 4 h after a single oral dose, but we were not able to detect [14C]beta-carotene in rat sera at any time up to 72 h after dosing. Small amounts of [14C]beta-carotene were found in the livers, although 88-94% of the recovered radioactivity was localized in the retinol fraction after saponification. Although radioactivity was also found in fractions other than beta-carotene and retinol, the amounts were too small to allow characterization. In the monkeys, peak accumulation of [14C]retinol in serum occurred between 8 and 24 h after supplementation. Some [14C]beta-carotene was also present. Most of the absorbed radioactivity was stored in the liver as [14C]retinol, although 2-8% was present as [14C]beta-carotene. Other organs also contained [14C]beta-carotene, confirming the ability of the monkey to absorb intact beta-carotene. In addition, monkey livers and other organs were found to contain lutein, zeaxanthin, alpha-cryptoxanthin, beta-cryptoxanthin and beta-carotene, presumably arising from dietary sources. |
| Databáze: | OpenAIRE |
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