Long-term progression of myopic maculopathy in degenerative myopia as imaged by SD-OCT and IR imaging
| Autor: | Georgios Smoustopoulos, Evgenia Kontou, Tina Xirou, Georgios Bontzos, Stamatina A. Kabanarou, Ilias Gkizis, Anastasia Gkiala, Miltiadis K. Tsilimbaris |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Visual Acuity Macular Degeneration 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Ophthalmology medicine Degenerative myopia Humans Longitudinal Studies Aged Retrospective Studies medicine.diagnostic_test business.industry Disease progression Macular atrophy food and beverages Middle Aged medicine.disease eye diseases Myopia Degenerative 030221 ophthalmology & optometry Maculopathy Female sense organs business Tomography Optical Coherence 030217 neurology & neurosurgery Follow-Up Studies Optometry |
| Zdroj: | Clinical and Experimental Optometry. 105:26-31 |
| ISSN: | 1444-0938 0816-4622 |
| Popis: | Clinicians can benefit from developing an understanding of the natural disease progression of myopic maculopathy in degenerative myopia using optical coherence tomography (OCT).The prevalence of high myopia is constantly increasing. In this work, infrared imaging and OCT is used to study the natural course of the disease.This is a retrospective longitudinal study. Medical records of 72 patients with high myopia (6.00 D) and a minimum five-year follow-up period were analysed. Collected data on all enrolled patients included demographic characteristics and medical history, as well as recordings on best-corrected visual acuity, slitlamp examination, OCT, and fluorescein angiography in cases of suspected myopic choroidal neovascularisation. Images were independently marked by two graders.The mean age of patients was 54.6 ± 14.4 years (59.72% female) with baseline logMAR best-corrected visual acuity of 0.22 ± 0.28. At baseline examination, 70.83% of the study group showed signs of maculopathy and 62.5% diffuse or patchy atrophy. During follow-up, 22.2% of patients with any type of atrophy showed enlarged affected areas. Two patients with baseline lacquer cracks developed new lesions. There was a weak correlation between patient age and maculopathy progression (r = 0.233; p = 0.03). While central retinal thickness was not associated with maculopathy progression (p = 0.203), a moderate correlation was found between choroidal thickness and maculopathy progression (r = -0.516; p 0.001).Lesion characteristics in myopic degeneration have been elucidated, taking advantage of the ongoing technological advances in retinal imaging. The understanding of disease patterns and progression is essential for appropriate management of patients, while discovering biomarkers which lead to choroidal neovascularisation development is of urgent importance to establish international diagnostic criteria and treatment protocols. |
| Databáze: | OpenAIRE |
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