The significance of α-defensins 1-3 in Behcet’s disease: a case-control study among Egyptian patients
Autor: | Mohamed Sherif Abd Elgawad, Reham M. Shaat, Samah H. El Meadawy, Tamer O. Elsaid, Ehsan Rizk |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Arthritis Disease Behcet's disease Diseases of the musculoskeletal system Gastroenterology Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine Salivary α-defensins 1-3 Medicine Sex organ 030203 arthritis & rheumatology Innate immunity Innate immune system business.industry Serum α-defensins 1-3 Case-control study medicine.disease IL6 RC925-935 030220 oncology & carcinogenesis Oral ulcers business Uveitis Behcet’s disease |
Zdroj: | Egyptian Rheumatology and Rehabilitation, Vol 47, Iss 1, Pp 1-8 (2020) |
ISSN: | 2090-3235 |
DOI: | 10.1186/s43166-020-00026-1 |
Popis: | Background Behcet’s disease (BD) is associated with uveitis, oral ulcers, genital ulcers and arthritis. Enhanced activity of innate immunity components, such as neutrophils, natural killer (NK) cells and endothelial cells, is a prominent feature of BD. The aim of this study was to clarify the significance of α-defensins 1-3 in BD and detect their correlation with disease activity, severity and oral ulcer activity. Results Significant differences were found between Behcet’s patients and controls as regards serum α-defensins 1-3 (median 10.1, IQR 4–45 μg/ml versus median 7.4, IQR 0.6–13.2 μg/ml, p = 0.001) and salivary α-defensins 1-3 (median 17.4, IQR 5.7–44 μg/ml versus median 8.6, IQR 3.3–11 μg/ml, p < 0.001). Receiver operating characteristic (ROC) showed a fair area under curve (AUC) (AUC = 0.743), with sensitivity of 40% and specificity 100% at cutoff value of 17.3 μg/ml for serum α-defensins 1-3, while salivary α-defensins 1-3 showed excellent AUC (AUC = 0.936), with sensitivity of 93.3% and specificity of 86.7% at cutoff value of 9.8 μg/ml. The levels of serum and salivary α-defensins 1-3 > cutoff value were significantly higher in active severe Behcet’s patients with active oral ulcers (p < 0.001). Conclusion α-Defensins 1-3 may be involved in the pathogenesis of BD and could be valuable markers in the determination of disease activity, severity and oral ulcer activity. |
Databáze: | OpenAIRE |
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