Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis[S]
| Autor: | Michael Doherty, Ana M. Valdes, Abhishek Abhishek, Petros Pousinis, Victoria Chapman, Massimo Mangino, Cristina Menni, Srinivasarao Ravipati, David A. Barrett |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Epoxide hydrolase 2 musculoskeletal diseases Male medicine.medical_specialty Epidemiology Linoleic acid Inflammation Osteoarthritis QD415-436 Biochemistry Polymorphism Single Nucleotide eicosanoids lipids 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Lipidomics medicine arachidonic acid Synovial fluid Humans Oxylipins methods/high-performance liquid chromatography Aged 030203 arthritis & rheumatology Epoxide Hydrolases Mass spectrometry business.industry Cell Biology Osteoarthritis Knee medicine.disease 030104 developmental biology chemistry Solubility inflammation Case-Control Studies Disease Progression lipidomics Arachidonic acid Female Prostaglandin D2 medicine.symptom business Patient-Oriented and Epidemiological Research Tomography X-Ray Computed |
| Zdroj: | Journal of Lipid Research Journal of Lipid Research, Vol 59, Iss 9, Pp 1763-1770 (2018) |
| ISSN: | 1539-7262 0022-2275 |
| Popis: | Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins) were measured using liquid chromatography-mass-spectrometry in synovial fluid from 112 knees of 102 individuals (knee OA n=58; controls n=44). Thsese were tested for association with presence of knee OA adjusting for covariates and NSAID use. Validation was performed in samples from 10 individuals with unilateral knee OA comparing affected to unaffected knees. Synovial fluid levels of three omega-6 oxylipins were associated with OA after adjusting for multiple comparisons: prostaglandin D2( PGD2), 11,12-dihydroxyeicosatrienoic acid (11,12-DHET) and 14,15-dihydroxyeicosatrienoic acid (14,15-DHET). Of these, 11,12-DHET and 14,15-DHET were also higher in affected vs unaffected knees from people with unilateral knee OA (p |
| Databáze: | OpenAIRE |
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