The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging
| Autor: | Thomas J. LaRocca, Christopher D. Link, Rachel A. Gioscia-Ryan, Andrew P. Neilson, Amy E Bazzoni, Vienna E. Brunt, Douglas R. Seals, Jill Miyamoto-Ditmon, Zachary J Sapinsley |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Aging Metabolite Trimethylamine N-oxide Inflammation Molecular medicine Gastrointestinal Microbiome chemistry.chemical_compound Methylamines Mice medicine.anatomical_structure Endocrinology Cognition chemistry Internal medicine medicine Animals Original Article Effects of sleep deprivation on cognitive performance Geriatrics and Gerontology medicine.symptom Cognitive decline Neuroinflammation Astrocyte |
| Zdroj: | GeroScience |
| ISSN: | 2509-2723 |
| Popis: | Aging is associated with declines in cognitive performance, which are mediated in part by neuroinflammation, characterized by astrocyte activation and higher levels of pro-inflammatory cytokines; however, the upstream drivers are unknown. We investigated the potential role of the gut microbiome–derived metabolite trimethylamine N-oxide (TMAO) in modulating neuroinflammation and cognitive function with aging. Study 1: In middle-aged and older humans (65 ± 7 years), plasma TMAO levels were inversely related to performance on NIH Toolbox Cognition Battery tests of memory and fluid cognition (both r(2) = 0.07, p |
| Databáze: | OpenAIRE |
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