Intrafamilial Aggregation and Heritability of Aortic Reflected (Backward) Waves Derived From Wave Separation Analysis
Autor: | Angela J. Woodiwiss, Pinhas Sareli, Andrew R. Raymond, Arnaud T. Djami-Tchatchou, Elena Libhaber, Bryan Hodson, Hendrik L. Booysen, Gavin R. Norton |
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Rok vydání: | 2015 |
Předmět: |
Adult
Male Applanation tonometry medicine.medical_specialty Black african Pulse Wave Analysis business.industry Reflected waves Middle Aged Heritability Wave separation Young Adult Central blood pressure Internal medicine Internal Medicine Cardiology Humans Medicine Original Article Arterial Pressure Female Statistical analysis business Aged |
Zdroj: | American Journal of Hypertension. 28:1427-1433 |
ISSN: | 1941-7225 0895-7061 |
Popis: | Although aortic wave reflection may be inherited, the extent to which indexes of wave reflection derived from wave separation analysis (reflected (backward) wave index (RI) and pressure (Pb)) show intrafamilial aggregation and heritability is uncertain. We therefore aimed to determine the intrafamilial aggregation and heritability of RI and Pb and compare these with indexes of pressure augmentation.Aortic Pb, RI, augmented pressure (Pa), and augmentation index (AIx) were determined using radial applanation tonometry and SphygmoCor software in 1,152 participants of 315 families (111 father-mother, 705 parent-child, and 301 sibling-sibling pairs) from an urban developing community of black Africans. Heritability estimates were determined from Statistical Analysis for Genetic Epidemiology software.With appropriate adjustments, significant correlations were noted between parent-child pairs for Pb and Pa (P0.05 for all), but not for RI (P = 0.50) or AIx (P = 0.90) and between sib-sib pairs for Pb and Pa (P0.05), but not for RI (P = 0.54) or AIx (P = 0.14). No correlations for indexes of wave reflection were noted between fathers and mothers (P0.57). After adjustments, Pb (h2 = 0.24±0.07) and Pa (h2 = 0.23±0.07) (P0.001 for both) but not RI (h2 = 0.04±0.06, P = 0.27) or AIx (h2 = 0.10±0.07, P = 0.07) showed significant heritability.Aortic reflected (backward) waves derived from either wave separation (Pb) or pulse wave analysis (Pa) show a similar degree of intrafamilial aggregation and heritability, but the use of RI or AIx may underestimate reflected wave effects. |
Databáze: | OpenAIRE |
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