A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia

Autor: Ka Wan Li, Andrea Schmitt, Jale Sahin, Michael R. Kreutz, Karl-Heinz Smalla, Eckart D. Gundelfinger, Marina Mikhaylova, H.-G. Bernstein, B. Bogerts, August B. Smit, R.C. van der Schors
Přispěvatelé: Molecular and Cellular Neurobiology, Neuroscience Campus Amsterdam 2008
Jazyk: angličtina
Rok vydání: 2008
Předmět:
Male
Proteome
Mass Spectrometry
Rats
Sprague-Dawley
0302 clinical medicine
Electrophoresis
Gel
Two-Dimensional
Prohibitin
Cells
Cultured
Cerebral Cortex
0303 health sciences
Mental Disorders
Glutamate receptor
Middle Aged
3. Good health
Psychiatry and Mental health
medicine.anatomical_structure
Cerebral cortex
Schizophrenia
NMDA receptor
Female
Ketamine
Psychopharmacology
Psychology
Subcellular Fractions
Adult
Psychosis
Green Fluorescent Proteins
Transfection
03 medical and health sciences
Cellular and Molecular Neuroscience
SDG 3 - Good Health and Well-being
Prohibitins
medicine
Animals
Humans
Molecular Biology
030304 developmental biology
Retrospective Studies
Analysis of Variance
Numerical Analysis
Computer-Assisted
medicine.disease
Rats
Dorsolateral prefrontal cortex
Repressor Proteins
Disease Models
Animal
Synapses
Neuroscience
030217 neurology & neurosurgery
Zdroj: Smalla, K H, Mikhaylova, M, Sahin, J, Bernstein, H G, Bogerts, B, Schmitt, A, van der Schors, R C, Smit, A B, Li, K W, Gundelfinger, E D & Kreutz, M R 2008, ' A comparison of the synaptic proteome in human chronic schizophrenia and rat ketamine psychosis suggest that prohibitin is involved in the synaptic pathology of schizophrenia ', Molecular Psychiatry, vol. 13, pp. 878-896 . https://doi.org/10.1038/mp.2008.60
Molecular Psychiatry, 13, 878-896. Nature Publishing Group
ISSN: 1359-4184
Popis: Many studies in recent years suggest that schizophrenia is a synaptic disease that crucially involves a hypofunction of N-methyl-D-aspartate receptor-mediated signaling. However, at present it is unclear how these pathological processes are reflected in the protein content of the synapse. We have employed two-dimensional gel electrophoresis in conjunction with mass spectrometry to characterize and compare the synaptic proteomes of the human left dorsolateral prefrontal cortex in chronic schizophrenia and of the cerebral cortex of rats treated subchronically with ketamine. We found consistent changes in the synaptic proteomes of human schizophrenics and in rats with induced ketamine psychosis compared to controls. However, commonly regulated proteins between both groups were very limited and only prohibitin was found upregulated in both chronic schizophrenia and the rat ketamine model. Prohibitin, however, could be a new potential marker for the synaptic pathology of schizophrenia and might be causally involved in the disease process. © 2008 Nature Publishing Group All rights reserved.
Databáze: OpenAIRE
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