PEGAylated graphene oxide/superparamagnetic nanocomposite as a high-efficiency loading nanocarrier for controlled delivery of methotrexate
| Autor: | Abolghasem Abbasi Kajani, Seyed Amir Bahrani, Asghar Taheri-Kafrani, Zahra Abdollahi |
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| Přispěvatelé: | Ecole nationale supérieure Mines-Télécom Lille Douai (IMT Lille Douai), Institut Mines-Télécom [Paris] (IMT) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
0301 basic medicine Biocompatibility Cell Survival Polymers Antineoplastic Agents Bioengineering Polyethylene glycol 01 natural sciences Applied Microbiology and Biotechnology Nanocomposites 03 medical and health sciences chemistry.chemical_compound [SPI]Engineering Sciences [physics] Drug Delivery Systems Neoplasms 010608 biotechnology Humans Magnetite Nanoparticles Cytotoxicity Cell Proliferation chemistry.chemical_classification Nanocomposite General Medicine Polymer Methotrexate 030104 developmental biology chemistry Chemical engineering Targeted drug delivery Drug delivery MCF-7 Cells Female Graphite Nanocarriers HeLa Cells Biotechnology |
| Zdroj: | Journal of Biotechnology Journal of Biotechnology, 2019, 298, pp.88-97. ⟨10.1016/j.jbiotec.2019.04.006⟩ |
| DOI: | 10.1016/j.jbiotec.2019.04.006⟩ |
| Popis: | Polymer-coated nanocarriers play an important role in targeted drug delivery. The use of polymers such as polyethylene glycol increases stability, biocompatibility, and blood circulation time of the drug, and may consequently improve the success of drug delivery. In the present work, a simple approach has been reported for synthesizing polyethylene glycol bis amin (PEGA) functionalized graphene oxide/iron oxide nanocomposite as a remarkable unit for loading drugs. The biomedical applications of the synthesized nanocomposite were investigated by immobilizing methotrexate (MTX), as an anticancer drug. The structural and morphological characteristics and the successful synthesis of the nanocomposite were evaluated by different charachterization techniques. The cytotoxicity assay of the nanocarrier showed higher toxicity against HeLa and MCF-7 cell lines, compared to free MTX. The drug release experiments in acidic and physiological conditions suggested the first order kinetics model for the release of MTX from the nanocomposite. Furthermore, the agglutination, complement activation, and coagulation time experiments demonstrated the blood compatibility of the synthesized nanocarrier. © 2019 Elsevier B.V. |
| Databáze: | OpenAIRE |
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