Cytokine production by CD4+ T-cells responding to antigen presentation by melanoma cells
| Autor: | Mary S. Brady, D. D. Eckels, J. S. Lee, S. Y. Ree, F Lee |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
CD4-Positive T-Lymphocytes
Cancer Research medicine.medical_treatment Antigen presentation Antigen-Presenting Cells Dermatology Biology Cell Line Interferon-gamma Antigen Tumor Cells Cultured medicine Humans Cytotoxic T cell Antigen-presenting cell Melanoma Interleukin 4 Reverse Transcriptase Polymerase Chain Reaction Interleukin-12 Interleukin-10 Interleukin 10 Cytokine Oncology Cancer research Interleukin 12 Cytokines Interleukin-2 Interleukin-4 |
| Zdroj: | Melanoma Research. 9:173-180 |
| ISSN: | 0960-8931 |
| DOI: | 10.1097/00008390-199904000-00010 |
| Popis: | Melanoma cells are unusual because, unlike most epithelial tumours, constitutive expression of HLA class II antigens is common. We have previously demonstrated that a peptide-specific CD4+ T-cell clone proliferates briskly in response to peptide and HLA class II expressing melanoma cell lines derived from metastases. Here we demonstrate that these CD4+ T-cells secrete large amounts of interferon-gamma (IFNgamma) and interleukin-10 (IL10), and insignificant quantities of IL2 or IL4, in response to peptide presentation by both melanoma and autologous B-cells. T-cells produced more IL10 when responding to peptide presentation by melanoma cells compared with B-cells, and less IFNgamma (P |
| Databáze: | OpenAIRE |
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