Interhemispheric distribution of amyloid and small vessel disease burden in cerebral amyloid angiopathy-related intracerebral hemorrhage
| Autor: | Nicolas Raposo, Alain Viguier, A.S. Salabert, Pierre Payoux, Jean-François Albucher, Federico Nemmi, Jérémie Pariente, Lionel Calviere, Patrice Péran, M. Planton, Jean-Marc Olivot |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Amyloid Standardized uptake value 03 medical and health sciences 0302 clinical medicine Cost of Illness mental disorders medicine Humans cardiovascular diseases 030212 general & internal medicine Cerebral Hemorrhage Intracerebral hemorrhage medicine.diagnostic_test business.industry Brain Magnetic resonance imaging medicine.disease Superficial siderosis Magnetic Resonance Imaging Hyperintensity nervous system diseases Cerebral Amyloid Angiopathy Neurology Positron emission tomography Neurology (clinical) Cerebral amyloid angiopathy business 030217 neurology & neurosurgery |
| Zdroj: | European journal of neurologyReferences. 27(8) |
| ISSN: | 1468-1331 |
| Popis: | Background and purpose Intracerebral hemorrhage (ICH) is a devastating presentation of cerebral amyloid angiopathy (CAA), but the mechanisms leading from vascular amyloid deposition to ICH are not well known. Whether amyloid burden and magnetic resonance imaging (MRI) markers of small vessel disease (SVD) are increased in the ICH-affected hemisphere compared to the ICH-free hemisphere in patients with a symptomatic CAA-related ICH was investigated. Methods Eighteen patients with CAA-related ICH and 18 controls with deep ICH who underwent brain MRI and amyloid positron emission tomography using 18 F-florbetapir were prospectively enrolled. In each hemisphere amyloid uptake using the standardized uptake value ratio and the burden of MRI markers of SVD including cerebral microbleeds, chronic ICH, cortical superficial siderosis, white matter hyperintensities and lacunes were evaluated. Interhemispheric comparisons were assessed by non-parametric matched-pair tests within each patient group. Results Amyloid burden was similarly distributed across the brain hemispheres in patients with CAA-related ICH (standardized uptake value ratio 1.11 vs. 1.12; P = 0.74). Cortical superficial siderosis tended to be more common in the ICH-affected hemisphere compared to the ICH-free hemisphere (61% vs. 33%; P = 0.063). Other MRI markers of SVD did not differ across brain hemispheres. In controls with deep ICH, no interhemispheric difference was observed either for amyloid burden or for MRI markers of SVD. Conclusions Brain hemorrhage does not appear to be directly linked to amyloid burden in patients with CAA-related ICH. These findings provide new insights into the mechanisms leading to hemorrhage in CAA. |
| Databáze: | OpenAIRE |
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