Gold-Catalyzed Cyclization of Allene-Substituted Malonate Esters: Synthesis of β,γ-Unsaturated δ-Lactones

Autor:	Patrik Krumlinde, Julio Piera, Jan-Erling Bäckvall, Dirk Strübing
Rok vydání:	2007
Předmět:	chemistry.chemical_compound Malonate Nucleophile Chemistry Allene Organic Chemistry Organic chemistry Moiety General Medicine Physical and Theoretical Chemistry Biochemistry Medicinal chemistry Catalysis
Zdroj:	ChemInform. 38
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200739117
Popis:	An efficient method for the preparation of beta,gamma-unsaturated delta-lactones has been developed. The starting materials for the synthesis of these compounds are allene-substituted malonates which undergo gold-catalyzed cyclization by means of nucleophilic attack of the ester moiety on the allene. It is worth mentioning that this is the first example where an ester group attacks as a nucleophile in a gold-catalyzed transformation of allenes.
Databáze:	OpenAIRE
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