Obesity and dysregulated innate immune responses : Impact of micronutrient deficiencies
| Autor: | Vrieling, F., Stienstra, R. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
obesity
Immunology immunometabolism Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6] micronutrient deficiencies Metabolism and Genomics macrophages Voeding Metabolisme en Genomica All institutes and research themes of the Radboud University Medical Center Voeding Metabolisme en Genomica Immunology and Allergy Nutrition Metabolism and Genomics Nutrition |
| Zdroj: | Trends in Immunology, 44, 3, pp. 217-230 Trends in Immunology 44 (2023) 3 Trends in Immunology, 44(3), 217-230 Trends in Immunology, 44, 217-230 |
| ISSN: | 1471-4906 |
| DOI: | 10.1016/j.it.2023.01.003 |
| Popis: | Item does not contain fulltext Obesity is associated with the development of various complications, including diabetes, atherosclerosis, and an increased risk for infections, driven by dysfunctional innate immune responses. Recent insights have revealed that the availability of nutrients is a key determinant of innate immune cell function. Although the presence of obesity is associated with overnutrition of macronutrients, several micronutrient deficiencies, including Vitamin D and zinc, are often present. Micronutrients have been attributed important immunomodulatory roles. In this review, we summarize current knowledge of the immunomodulatory effects of Vitamin D and zinc. We also suggest future lines of research to further improve our understanding of these micronutrients; this may serve as a stepping-stone to explore micronutrient supplementation to improve innate immune cell function during obesity. |
| Databáze: | OpenAIRE |
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