Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
| Autor: | King Hwa Ling, Tim Thomas, Kai-Leng Tan, Pike See Cheah, Chelsee A. Hewitt, Melanie April Pritchard, Lavinia Gordon, Hamish S. Scott, Gordon K. Smyth, Ken M. Simpson |
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| Přispěvatelé: | Tan, Kai-Leng, Ling, King-Hwa, Hewitt, Chelsee A, Cheah, Pike-See, Simpson, Ken, Gordon, Lavinia, Pritchard, Melanie A, Smyth, Gordon K, Thomas, Tim, Scott, Hamish S |
| Rok vydání: | 2014 |
| Předmět: |
Down syndrome
Cerebellum lcsh:QH426-470 Microarray Biology Biochemistry Transcriptome 03 medical and health sciences 0302 clinical medicine Chromosome 16 Gene expression Data in Brief Genetics medicine 030304 developmental biology 0303 health sciences medicine.disease postnatal brain Cell biology lcsh:Genetics medicine.anatomical_structure Postnatal brain Cerebral cortex gene expression Molecular Medicine Chromosome 21 microarray 030217 neurology & neurosurgery Biotechnology |
| Zdroj: | Genomics Data Genomics Data, Vol 2, Iss C, Pp 314-317 (2014) |
| ISSN: | 2213-5960 |
| Popis: | The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learning and memory [2,3]. To understand the global gene expression effect of the partially triplicated MMU16 segment on mouse brain development, we performed the spatiotemporal transcriptome analysis of Ts1Cje and disomic control cerebral cortex, cerebellum and hippocampus harvested at four developmental time-points: postnatal day (P)1, P15, P30 and P84. Here, we provide a detailed description of the experimental and analysis procedures of the microarray dataset, which has been deposited in the Gene Expression Omnibus (GSE49050) database. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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