Effects of vitamin D3metabolites on thyrotropin secretion from rat pituitary cells in culture
| Autor: | Christel Lamberg-Allardt, Kid Törnquist, L Forss |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Vitamin endocrine system Pituitary gland medicine.medical_specialty 24 25-Dihydroxyvitamin D 3 endocrine system diseases Endocrinology Diabetes and Metabolism Thyrotropin Biology Basal (phylogenetics) chemistry.chemical_compound Endocrinology Calcitriol Internal medicine medicine Animals Secretion Vitamin D Incubation Cells Cultured Calcifediol Dose-Response Relationship Drug Hydroxycholecalciferols Rats Inbred Strains In vitro Rats Rat Pituitary medicine.anatomical_structure chemistry Cell culture Pituitary Gland Female hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Endocrinological Investigation. 13:391-395 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03350686 |
| Popis: | The effects of several vitamin D3 metabolites on TSH secretion were investigated using rat pituitary cells in culture. After a 24-h incubation in Dulbecco's medium, only 25,26-dihydroxyvitamin D3 [25,26(OH)2D3] at 10(-6) M increased the basal TSH secretion (36% above control). The TRH-induced TSH secretion increased dose-dependently with increasing concentrations of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] showing a significant increase at 10(-8) M (41% above control). At 10(-5) M 25,26(OH)2D3 the TRH-stimulated TSH secretion was also increased (63% above control). In medium containing charcoal-treated serum, 1, 24,25-trihydroxyvitamin D3 [1,24,25(OH)3D3] decreased the TRH-induced TSH secretion dose dependently (34% below control at 10(-8) M), while the effects of both 1,25(OH)2D3 and 25,26(OH)2D3 were blunted. Our results indicate that several vitamin D3 metabolites may affect pituitary TSH secretion. |
| Databáze: | OpenAIRE |
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