Micronutrients, Immunological Parameters, and Dengue Virus Infection in Coastal Ecuador: A Nested Case-Control Study in an Infectious Disease Surveillance Program
| Autor: | Timothy P. Endy, Saurabh Mehta, Julia L. Finkelstein, Julia M. Tedesco, Washington B. Cárdenas, Mark Polhemus, Susannah Colt, Anna M. Stewart-Ibarra, Efraín Beltrán-Ayala, Alexander J Layden, Jesse T Krisher |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Adolescent Fever 030231 tropical medicine Nutritional Status Dengue virus medicine.disease_cause Body Mass Index Dengue fever Dengue Young Adult Major Articles and Brief Reports 03 medical and health sciences 0302 clinical medicine medicine Vitamin D and neurology Body Size Humans Immunology and Allergy Micronutrients Vitamin B12 Vitamin D Soluble transferrin receptor Interleukin-15 biology business.industry Orosomucoid Odds ratio medicine.disease Micronutrient C-Reactive Protein 030104 developmental biology Infectious Diseases Case-Control Studies Population Surveillance Ferritins Nested case-control study Immunology biology.protein Female Ecuador business Retinol-Binding Proteins Plasma Biomarkers |
| Zdroj: | J Infect Dis |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background Micronutrients are known to modulate host immunity, and there is limited literature on this association in the context of dengue virus infection (DENV). Methods Using a nested case-control design in a surveillance program, we measured the following: anthropometry; nutritional biomarkers including serum ferritin, soluble transferrin receptor, retinol-binding protein (RBP), 25-hydroxy vitamin D, folate, and vitamin B12; and a panel of immune response markers. We then compared these measures across 4 illness categories: healthy control, nonfebrile DENV, other febrile illness (OFI), and apparent DENV using multivariate polytomous logistic regression models. Results Among 142 participants, serum ferritin (ng/mL) was associated with apparent DENV compared to healthy controls (odds ratio [OR], 2.66; confidence interval [CI], 1.53–4.62; P = .001), and RBP concentrations (µmol/L) were associated with apparent DENV (OR, 0.03; CI, 0.00–0.30; P = .003) and OFI (OR, 0.02; CI, 0.00–0.24; P = .003). In a subset of 71 participants, interleukin-15 levels (median fluorescent intensity) were positively associated with apparent DENV (OR, 1.09; CI, 1.03–1.14; P = .001) and negatively associated with nonfebrile DENV (OR, 0.89; CI, 0.80–0.99; P = .03) compared to healthy controls. Conclusions After adjusting for the acute-phase response, serum ferritin and RBP concentrations were associated with apparent DENV and may represent biomarkers of clinical importance in the context of dengue illness. |
| Databáze: | OpenAIRE |
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