Intrinsic functional connectivity of fronto-temporal networks in adolescents with early psychosis
| Autor: | Olga Puig, Núria Bargalló, Josefina Castro-Fornieles, Inmaculada Baeza, Cristina Solé-Padullés, Gisela Sugranyes, Vanessa Sánchez-Gistau, Elena de la Serna, Soledad Romero, Anna Calvo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Psychosis Adolescent Inferior frontal gyrus Audiology Developmental psychology 03 medical and health sciences 0302 clinical medicine Neuroimaging Fractional anisotropy Developmental and Educational Psychology medicine Humans Child Association (psychology) medicine.diagnostic_test Early psychosis General Medicine medicine.disease Magnetic Resonance Imaging Frontal Lobe 030227 psychiatry Psychiatry and Mental health Psychotic Disorders Pediatrics Perinatology and Child Health Female Psychology Functional magnetic resonance imaging 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | European Child & Adolescent Psychiatry. 26:669-679 |
| ISSN: | 1435-165X 1018-8827 |
| Popis: | Adults with psychotic disorders have abnormal connectivity of fronto-temporal networks. However, whether these abnormalities are present in adolescents with early psychosis has not been fully assessed. One-hundred and thirty-nine adolescents aged 12-18 underwent resting-state functional magnetic resonance imaging and diffusion tensor imaging. Following motion correction, data were available for 44 participants with a psychosis risk syndrome, 34 patients with a first episode psychosis (FEP) and 35 healthy controls. Independent component analysis was performed to assess functional networks showing a fronto-temporal scope; this identified a language and a salience network. Mean fractional anisotropy was measured in clusters showing between-group differences in intrinsic functional connectivity (iFC). For the language network, there was a group effect within the right middle/inferior frontal gyrus, explained by reduced iFC in patients with an FEP relative to healthy controls, while in participants with a psychosis risk syndrome values of iFC were intermediate. In this region, values of iFC were positively correlated with mean fractional anisotropy in patients with an FEP. No group differences were observed in the salience network. Reduced iFC of the language network, in association with disrupted white matter microstructure, may characterize FEP during adolescence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink