Oxidative stress in patients with acute heart failure
Autor: | Dominique Bonnefont-Rousselot, Alain Legrand, Noelle Vignat, Jean-Christophe Charniot, Jean-Yves Artigou, Vera Bogdanova, Khaled Zerhouni, Jean-Paul Albertini, Jean-Jacques Monsuez |
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Rok vydání: | 2008 |
Předmět: |
Adult
Male Aging Acute coronary syndrome medicine.medical_specialty Cardiomyopathy Internal medicine medicine Humans cardiovascular diseases Aged Heart Failure biology business.industry Angiotensin-converting enzyme Dilated cardiomyopathy Middle Aged medicine.disease Pulmonary edema Cardiac surgery Transplantation Oxidative Stress Heart failure Acute Disease biology.protein Cardiology Female Geriatrics and Gerontology business |
Zdroj: | Rejuvenation research. 11(2) |
ISSN: | 1549-1684 |
Popis: | Oxidative stress (OS) is a keystone in the pathology of the ischemia reperfusion sequence (acute coronary syndromes, cardiac surgery, transplantation). In heart failure, the implication of OS is less understood. This study was intended to evaluate OS in acute heart failure. Criteria for inclusion were consecutive patients hospitalized in our cardiology department for a first pulmonary edema that revealed a dilated cardiomyopathy (DCM). Exclusion criteria included known cardiomyopathy, smoker, acute coronary syndrome, and treatment with angiotensin converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARAII). OS was evaluated in blood samples: thiobarbituric acid-reactive substances (TBARS), total antioxidant status (TAS), plasma alpha-tocopherol, vitamin A, and beta-carotene. Standard biochemical parameters including CRP, fibrinogen, lipid, and creatinine were assayed. Ten patients (80% men, mean age 55.3 +/- 7.9 years) were included and followed during a 6 month period. The etiologies of DCM were alcohol (n = 3), anti-cancer drugs (n = 2), valvulopathies (n = 2), or idiopathic (n = 3). In acute heart failure, TBARS were elevated (1.69 micromol/L; normal value 0.6-4.2 micromol/L) and TAS status was decreased (0.96 mmol/L; normal value 1.3-1.9 pmol/L). OS was more important when patients had atrial or ventricular arrhythmia. Nevertheless, liposoluble antioxidant parameters (beta-carotene, vitamin A, alpha-tocopherol) had a usual value. At the term of the follow-up, patients returned to a stable condition, OS markers revealed normal values, and every Holter ECG showed no supraventricular or ventricular arrhythmias. In acute heart failure, oxygen-free radicals are increased. We thus hypothetized that a modification in OS could be responsible for arrhythmias and complications of acute heart failure. |
Databáze: | OpenAIRE |
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