Neuronal Small RNAs Control Behavior Transgenerationally
| Autor: | Oded Rechavi, Rachel Posner, Hila Gingold, Sarit Anava, Michael Hendricks, Itai Antoine Toker, Ekaterina Star, Olga Antonova, Eran Azmon, Shahar Bracha |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Neurons
0303 health sciences Small interfering RNA Small RNA biology Behavior Animal Argonaute biology.organism_classification General Biochemistry Genetics and Molecular Biology Germline Cell biology 03 medical and health sciences 0302 clinical medicine Gene expression Argonaute Proteins Gene silencing Animals RNA Small Untranslated Epigenetics RNA Helminth Caenorhabditis elegans Caenorhabditis elegans Proteins 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Cell. 177(7) |
| ISSN: | 1097-4172 |
| Popis: | It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis elegans nematodes, parental responses can transmit heritable small RNAs that regulate gene expression transgenerationally. In this study, we show that a neuronal process can impact the next generations. Neurons-specific synthesis of RDE-4-dependent small RNAs regulates germline amplified endogenous small interfering RNAs (siRNAs) and germline gene expression for multiple generations. Further, the production of small RNAs in neurons controls the chemotaxis behavior of the progeny for at least three generations via the germline Argonaute HRDE-1. Among the targets of these small RNAs, we identified the conserved gene saeg-2, which is transgenerationally downregulated in the germline. Silencing of saeg-2 following neuronal small RNA biogenesis is required for chemotaxis under stress. Thus, we propose a small-RNA-based mechanism for communication of neuronal processes transgenerationally. |
| Databáze: | OpenAIRE |
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