Cycling through metabolism
| Autor: | Victor Aguilar, Lluis Fajas |
|---|---|
| Přispěvatelé: | Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Agence Nationale pour la Recherche (ANR physio), Association pour la Recherche contre le Cancer, Institut National du Cancer (INCA), and Fondation pour la Recherche Médicale (FRM). V.A. is supported by a grant of the FRM. Glossary |
| Rok vydání: | 2010 |
| Předmět: |
obesity
Cell Cycle Proteins MESH: Metabolic Diseases [SDV.CAN]Life Sciences [q-bio]/Cancer Context (language use) Review Mice 03 medical and health sciences MESH: Cell Cycle Proteins 0302 clinical medicine Metabolic Diseases Cyclin-dependent kinase Cyclins Animals cancer MESH: Animals [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Cell Cycle Protein E2F MESH: Mice 030304 developmental biology Cyclin 0303 health sciences Adipogenesis diabetes biology Cell growth MESH: Energy Metabolism [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism Cell cycle MESH: Cyclins Cyclin-Dependent Kinases E2F Transcription Factors Cell biology MESH: Cyclin-Dependent Kinases Cell metabolism MESH: E2F Transcription Factors 030220 oncology & carcinogenesis biology.protein Molecular Medicine cell cycle Energy Metabolism metabolism MESH: Adipogenesis |
| Zdroj: | EMBO Molecular Medicine EMBO Molecular Medicine, Wiley Open Access, 2010, 2 (9), pp.338-48. ⟨10.1002/emmm.201000089⟩ |
| ISSN: | 1757-4684 1757-4676 |
| Popis: | International audience; Since the discovery of cyclins, the role of cell cycle regulators in the control of cell proliferation has been extensively studied. It is clear that proliferation requires an adapted metabolic response of the cells; hence the regulation of cell cycle must be linked to metabolic control. While at a much slower pace, the impact that the activities of cell cycle regulators such as cyclins, cyclin dependent kinases or E2F factor, transcription factor have on cell metabolism are also being uncovered. Here we will focus on recent data implicating cell cycle regulators in metabolic control, with particular attention to studies performed using mouse models. Furthermore, we will discuss the possible relevance of these findings in the context of metabolic disorders such as obesity or diabetes. |
| Databáze: | OpenAIRE |
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