Mapping the Follicle-Stimulating Hormone-Induced Signaling Networks
| Autor: | Anne Poupon, Pascale Crépieux, Eric Reiter, Domitille Heitzler, Pauline Gloaguen |
|---|---|
| Přispěvatelé: | Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Centre National de la Recherche Scientifique (CNRS)-Université de Tours-Institut Français du Cheval et de l'Equitation [Saumur]-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Cell signaling
endocrine system Endocrinology Diabetes and Metabolism Systems biology [SDV]Life Sciences [q-bio] receptor Regulator 030209 endocrinology & metabolism Context (language use) Review Article topological map Biology Bioinformatics lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Follicle-stimulating hormone 0302 clinical medicine Endocrinology Functional selectivity signalling networks HORMONE GONADOTROPE follicle-stimulating hormone 030304 developmental biology follicle stimulating hormone 0303 health sciences lcsh:RC648-665 Mechanism (biology) systems biology réseau de signalisation signaling network fsh Signal transduction Neuroscience hormones hormone substitutes and hormone antagonists |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Frontiers, 2011, 2 (Article 45), pp.1-13. ⟨10.3389/fendo.2011.00045⟩ Frontiers in Endocrinology, Vol 2 (2011) |
| ISSN: | 1664-2392 |
| Popis: | Follicle-stimulating hormone (FSH) is a central regulator of male and female reproductive function. Over the last decade, there has been a growing perception of the complexity associated with FSH-induced cellular signalling. It is now clear that the canonical Gs/cAMP/PKA pathway is not the sole mechanism that must be considered in FSH biological actions. In parallel, consistent with the emerging concept of biased agonism, several examples of ligand-mediated selective signalling pathway activation by gonadotropin receptors have been reported. In this context, it is important to gain an integrative view of the signalling pathways induced by FSH and how they interconnect to form a network. In this review, we propose a first attempt at building topological maps of various pathways known to be involved in the FSH-induced signalling network. We discuss the multiple facets of FSH-induced signalling and how they converge to the hormone integrated biological response. Despite of their incompleteness, these maps of the FSH-induced signalling network represent a first step towards gaining a system-level comprehension of this hormone’s actions, which may ultimately facilitate the discovery of novel regulatory processes and therapeutic strategies for infertilities and non-steroidal contraception. |
| Databáze: | OpenAIRE |
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