Effects of pioglitazone and retinoic acid in a rotenone model of Parkinson's disease

Autor: Hakan Kayir, Tayfun Uzbay, Murat Gürsoy, Ahmet Turan Isik, Turgay Celik, Gokhan Ulusoy
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı., Gürsoy, Murat
Rok vydání: 2011
Předmět:
Male
Parkinson's disease
Dopamine
Retinoic acid
Striatum
Pharmacology
Hippocampus
Antioxidants
Corpus striatum
chemistry.chemical_compound
Pioglitazone
2 Chloro 5 Nitrobenzanilide
Peroxisome Proliferator-Activated Receptors
Inhibition
Priority journal
Neurons
Gamma agonist pioglitazone
General Neuroscience
Neurochemistry
Neuroprotection
Parkinson disease
Rat(s)
Neuroprotective Agents
Locomotion
Receptor
medicine.drug
medicine.medical_specialty
Mptp model
Hypothalamus
Antineoplastic Agents
Tretinoin
Motor Activity
Biology
Neurosciences & neurology
Article
Mouse model
Exposure
Alpha-synuclein
Rotenone
Internal medicine
medicine
Dopamine brain level
Animals
Hypoglycemic Agents
Animal model
Animal experiment
Parkinson Disease
Secondary
Rats
Wistar
Neurosciences
Nonhuman
medicine.disease
Rats
Drug effect
Disease Models
Animal
Endocrinology
chemistry
Degeneration
Rat
Thiazolidinediones
Controlled study
Zdroj: Brain Research Bulletin. 85:380-384
ISSN: 0361-9230
DOI: 10.1016/j.brainresbull.2011.05.001
Popis: Parkinson's disease (PD) is a late-onset, progressive and neurodegenerative disorder of unknown etiology. Besides the other therapeutic approaches, new drug options in pharmacotherapy of PD are important. The aim of the present study was to investigate the effects of pioglitazone and retinoic acid, antioxidant and neuroprotective agents, on rotenone-induced model of PD in rats. Adult male Wistar rats (260-373 g) were subjects. Rotenone (2.5 mg/kg, sc) was injected to rats for 70 days. At the end of rotenone administration, rats were treated with pioglitazone (10 mg/kg, ip) and retinoic acid (1 mg/kg, ip) or vehicles for 15 days. Then, rats were tested for evaluation of Parkinson signs by measurement of locomotor activity. In addition, dopamine levels were detected in striatum, hippocampus and hypothalamus in individual groups of control, rotenone and pioglitazone or retinoic acid-treated rats. Rotenone significantly reduced locomotor activity of the rats. It also significantly reduced dopamine levels in striatum and hippocampus, but not hypothalamus. Pioglitazone and retinoic acid reversed in reduction of locomotor activity significantly. Pioglitazone, but not retinoic acid, significantly reversed the reduced striatal dopamine level. Both drugs were ineffective on reduced levels of dopamine in hippocampus. Our results suggest that pioglitazone and retinoic acid have some beneficial effects on rotenone-induced model of PD in rats. Pioglitazone seems to be more effective than retinoic acid. These agents may be helpful for preventing or controlling of some signs of PD. Scientific Research Committee of Gulhane Military Medical Academy (GATA) (AR-2008/25)
Databáze: OpenAIRE
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