Deciphering natural control of HIV-1: A valuable strategy to achieve antiretroviral therapy termination
| Autor: | Simona Stäger, Julien van Grevenynghe, Armstrong Murira, Xavier Dagenais-Lussier, Steven Gouard, Cécile Tremblay, Hamza Loucif |
|---|---|
| Přispěvatelé: | Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), Université de Montréal (UdeM) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Chronic condition Anti-HIV Agents [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Immunology HIV Infections Inflammation Antiviral immunity Virus Replication Bioinformatics General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Immune system Insulin resistance Antiretroviral Therapy Highly Active Humans Immunology and Allergy Medicine Controllers business.industry Microbiota Viral Load medicine.disease Antiretroviral therapy Metabolism 030104 developmental biology Viral replication Host-Pathogen Interactions HIV-1 medicine.symptom Lipodystrophy Cure business ART |
| Zdroj: | Cytokine and Growth Factor Reviews Cytokine and Growth Factor Reviews, Elsevier, 2018, 40, pp.90-98. ⟨10.1016/j.cytogfr.2018.03.010⟩ |
| ISSN: | 1359-6101 |
| DOI: | 10.1016/j.cytogfr.2018.03.010 |
| Popis: | International audience; Antiretroviral therapy (ART) has dramatically reduced HIV-1-associated morbidity and mortality, and has transformed HIV-1 infection into a manageable chronic condition by suppressing viral replication. However, despite recent patient care improvements, ART still fails to cure HIV-1 infection due to the inability to counteract immune defects and metabolic disturbances that are associated with residual inflammation alongside viral persistence. Life-long drug administration also results in multiple side-effects in patients including lipodystrophy and insulin resistance. Thus, it is critical to find new ways to reduce the length of treatment and facilitate the termination of ART, for example by boosting protective immunity. The rare ability of some individuals to naturally control HIV-1 infection despite residual inflammation could be exploited to identify molecular mechanisms involved in host protection that may function as potential therapeutic targets. In this review, we highlight evidence illustrating the molecular and metabolic advantages of HIV-1 controllers over ART treated patients that contribute to the maintenance of effective antiviral immunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect