Dansyl acetyl trehalose: a novel tool to investigate the cellular fate of trehalose
| Autor: | Giovanna Farruggia, Stefano Iotti, Anna Maria Porcelli, Emil Malucelli, Luisa Iommarini, Giovanni Venturoli, Alessandra Locatelli, Francesco Francia, Alberto Leoni, Alessandra Graziadio |
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| Přispěvatelé: | Alessandra Locatelli, Luisa Iommarini, Alessandra Graziadio, Alberto Leoni, Anna Maria Porcelli, Stefano Iotti, Emil Malucelli, Francesco Francia, Giovanni Venturoli, Giovanna Farruggia |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
General Chemical Engineering
Vesicle 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Trehalose Fluorescence Fluorescence spectroscopy 0104 chemical sciences chemistry.chemical_compound symbols.namesake chemistry Permeability (electromagnetism) Trehalose dansyl acetyl trehalose (DAT) fluorescence spectroscopy fluorescence microscopy Lipid droplet Stokes shift Biophysics Fluorescence microscope symbols 0210 nano-technology |
| Popis: | A fluorescent derivative of trehalose with two dansyl groups (DAT) has been synthesized. It is characterised by a large Stokes shift, good permeability in human living cells and a well detectable fluorescent signal within the cells. Notably, in intestinal cells DAT is sequestered in vesicles induced by trehalose pre-treatment and colocalizes with lipid droplets. |
| Databáze: | OpenAIRE |
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