Cytomegalovirus-induced Hemorrhagic Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) on Dasatinib as an Upfront Therapy
| Autor: | Afra Moustafa, Radwa M Hussein, Abbas Moustafa, Afaf AlBattah, Samah Kohla, Mohamed A. Yassin, Hatim El Derhoubi, Anil Yousif, Sarra Boukhris, Nader Al-Dewik, Ashraf T Soliman, Sarah Elkourashy, Abdulqadir J. Nashwan, Deena Mudawi, Deena-Raiza Asaari, Mohamed Almusharaf, Shehab F. Mohamed, Hope-Love G. Gutierrez |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology Myeloid colitis Nausea Case Report Gastroenterology hemic and lymphatic diseases Internal medicine medicine dasatinib Colitis CML lcsh:R5-920 business.industry Myeloid leukemia Imatinib General Medicine medicine.disease Rash Dasatinib Diarrhea medicine.anatomical_structure medicine.symptom business lcsh:Medicine (General) medicine.drug |
| Zdroj: | Clinical Medicine Insights: Case Reports, Vol 2015, Iss 8, Pp 77-81 (2015) Clinical Medicine Insights. Case Reports Clinical Medicine Insights: Case Reports, Vol 8 (2015) |
| ISSN: | 1179-5476 |
| Popis: | Dasatinib is a kinase inhibitor indicated for the treatment of newly diagnosed adults with Philadelphia chromosome–positive (Ph+) chronic myeloid leukemia (CML) in chronic phase and accelerated (myeloid or lymphoid blast) phase, and CML with resistance or intolerance to prior therapy including imatinib and in adults with Ph+ acute lymphoblastic leukemia 1 The most common adverse reactions (≥15%) in patients with newly diagnosed chronic-phase (CP) CML include myelosuppression, fluid retention, and diarrhea, whereas in patients with resistance or intolerance to prior imatinib therapy, side effects include myelosuppression, fluid retention, diarrhea, headache, dyspnea, skin rash, fatigue, nausea, and hemorrhage. We report a 39-year-old Ethiopian female patient who received dasatinib as upfront therapy for the treatment of CP-CML who experienced chronic diarrhea for two months, which progressed to hemorrhagic colitis due to cytomegalovirus (CMV) infection of the colon. To our knowledge, this is the first case of CMV colitis in a patient receiving dasatinib as upfront therapy. |
| Databáze: | OpenAIRE |
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