The topographical distribution of epileptic spikes in juvenile myoclonic epilepsy with and without photosensitivity
| Autor: | Gergard Visser, Josemir W. Sander, N.E.C. van Klink, Prisca R. Bauer, K. Gorgels, Willy P. J. Spetgens, Maeike Zijlmans, Frans S. S. Leijten |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Neurology Adolescent Photic Stimulation Clinical Neurology Action Potentials Electroencephalography Brain mapping Epilepsy Reflex 03 medical and health sciences Epilepsy Young Adult 0302 clinical medicine Juvenile myoclonic epilepsy Photosensitivity Physiology (medical) medicine Journal Article Humans Comparative Study Intermittent photic stimulation Child Brain Mapping medicine.diagnostic_test business.industry Myoclonic Epilepsy Juvenile medicine.disease Sensory Systems Electrophysiology 030104 developmental biology Interictal discharges Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurophysiology, 128(1), 176. Elsevier Ireland Ltd |
| ISSN: | 1872-8952 1388-2457 |
| Popis: | Objective Up to 30% of people with juvenile myoclonic epilepsy (JME) have photoparoxysmal responses (PPR). Recent studies report on structural and pathophysiological differences between people with JME with (JME+PPR) and without PPR (JME−PPR). We investigated whether electrophysiological features outside photic stimulation differ between these subtypes. Methods We analysed EEG recordings of people with JME at a tertiary epilepsy centre and an academic hospital. Photosensitivity was assessed in a drug-naïve condition. We compared the occurrence and involvement of posterior electrodes for focal abnormalities and generalised spike-wave activity in the EEG outside photic stimulation between JME+PPR and JME−PPR. Results We included EEG recordings of 18 people with JME+PPR and 21 with JME−PPR. People with JME−PPR had less focal abnormalities in the posterior brain regions than people with JME+PPR (19% vs 55%, p |
| Databáze: | OpenAIRE |
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