Effect of Topical Olopatadine And Epinastine in The Botulinum Toxin B—Induced Mouse Model of Dry Eye
| Autor: | Kaevalin Lekhanont, Roy S. Chuck, Olan Suwan-apichon, Ram Rangsin, Juan Castro Combs, Choul Yong Park |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Botulinum Toxins Administration Topical Eye disease medicine.medical_treatment Epinastine Keratoconjunctivitis Sicca Lacrimal gland Mice Dibenzazepines Ophthalmology medicine Animals Pharmacology (medical) Botulinum Toxins Type A Olopatadine Hydrochloride Pharmacology business.industry Imidazoles Eye drop Olopatadine medicine.disease Botulinum toxin eye diseases Surgery Disease Models Animal medicine.anatomical_structure Tears Lubricant Eye Drops Histamine H1 Antagonists Mice Inbred CBA Female business Dibenzoxepins medicine.drug |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 23:83-88 |
| ISSN: | 1557-7732 1080-7683 |
| DOI: | 10.1089/jop.2006.0097 |
| Popis: | The aim of this study was to compare the effect of topical olopatadine, epinastine, and lubricant eye drops on dry eye ocular surface disease in the botulinum toxin B (BTX-B)-induced mouse model of keratoconjunctivitis sicca.CBA/J mice were randomized into 3 experimental groups of 10 animals each. All mice received a transconjunctival injection of 0.05 mL of 20-mU BTX-B solutions into the left lacrimal gland. Three (3) days after intralacrimal gland injections, each group received treatment with twice-daily topical lubricant as a control, 0.1% olopatadine, or 0.05% epinastine eye drops. To monitor the progression of dry eye tear production, an ocular surface fluorescein staining score was evaluated in each of the 3 experimental groups.Three (3) days after the intralacrimal gland injection of BTX-B, aqueous tear production was significantly decreased (1.95+/-0.64 mm), compared to baseline level (2.69+/-0.66 mm; P0.001). Similarly, there was a statistically significant increase in the proportion of mice with a corneal staining score of 2 or greater at 3 days postinjection, compared to the preinjection value (P0.001). There were no statistically significant differences in aqueous tear production between the 3 different medication groups at all time points. Aqueous tear production in neither the olopatadine nor the epinastine-challenged groups was further decreased compared to the lubricant-treated group. Difference in the proportion of mice with a low- and high corneal staining score between the control and study groups did not reach statistical significance throughout the 4-week experimental period. In addition, changes in corneal fluorescein staining of the olopatadine group versus the epinastine group did not show a statistically significant difference.Topical olopatadine and epinastine do not cause significantly additional damage to the compromised ocular surface secondary to dry eye after continuous 4-week, twice-daily application. Topical olopatadine and epinastine appear to have comparable effects on aqueous tear-production and corneal-surface changes in this mouse model. |
| Databáze: | OpenAIRE |
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