Carbonic anhydrase inhibitory properties of phenolic sulfonamides derived from dopamine related compounds
| Autor: | Süleyman Göksu, Akın Akıncıoğlu, İlhami Gülçin, Hülya Göçer |
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| Přispěvatelé: | Belirlenecek, GULCIN, Ilhami -- 0000-0001-5993-1668 |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Chemistry(all)
General Chemical Engineering Inhibitory postsynaptic potential 01 natural sciences Esterase Isozyme lcsh:Chemistry Affinity chromatography Dopamine Carbonic anhydrase Ic50 values medicine Chromatography biology 010405 organic chemistry Chemistry Phenolic sulfonamides General Chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry Cytosol Enzyme inhibition lcsh:QD1-999 Biochemistry Chemical Engineering(all) biology.protein medicine.drug |
| Zdroj: | Arabian Journal of Chemistry, Vol 10, Iss 3, Pp 398-402 (2017) |
| Popis: | The effects of some phenolic sulfonamides were determined on the cytosolic carbonic anhydrase isoenzyme I and II (hCA I and II). Both isoenzymes were purified separately from human erythrocytes, using the Sepharose-4B-L-tyrosine-sulfanilamide affinity column chromatography method. In continuation of the study, we identified the inhibitory effects of phenolic sulfonamides 1-4 on the esterase activity of hCA I, and II. The inhibitory effects of phenolic sulfonamides 1-4 were tested on human carbonic anhydrase isoenzymes hCA I, and II. Among the compounds 14, compound 1 was concluded to show the best inhibitory effects. According to our data, IC50 values of compound 1 were found as 3.55 and 2.94 mu M for hCA I, and hCA II, respectively. On the other hand, K-i values of this compound were found as 0.827 and 0.745 mu M for both isoenzymes, respectively. (C) 2014 King Saud University. Production and hosting by Elsevier B.V. Deanship of Scientific Research at the King Saud University [RGP-VPP-254] The authors would like to extend their sincere appreciation to the Deanship of Scientific Research at the King Saud University for funding this research through the Research Group Project no. RGP-VPP-254. |
| Databáze: | OpenAIRE |
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