Circulating immune complexes, immunoglobulin classes (IgG, IgA and IgM) and complement components (C3c, C4 and Factor B) in diabetic Nigerians
| Autor: | L. S. Salimonu, G.O. Oyeyinka, Olatunbosun Ganiyu Arinola, K. S. Akinlade |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
medicine.medical_specialty Nigeria Complement factor I Antigen-Antibody Complex Complement factor B Immune complexes Immuno-globulins Complement factor Diabetic mellitus Deranged Insulin resistance Diabetes mellitus medicine Humans Aged Gynecology biology business.industry Nigerians Type 2 Diabetes Mellitus Complement C4 General Medicine Middle Aged medicine.disease Immunoglobulin A Diabetes Mellitus Type 1 Diabetes Mellitus Type 2 Immunoglobulin M Case-Control Studies Complement C3c Immunoglobulin G Immunology Humoral immunity biology.protein Antibody business Complement Factor B |
| Zdroj: | West African Journal of Medicine; Vol 23, No 3 (2004); 253-255 |
| ISSN: | 0189-160X |
| Popis: | Objective:- To evaluate serum levels of circulating immune complexes (CICs), immunoglobulin classes (IgG, IgA and IgM) and Complement Components (C3c, C4 and Factor B) in Nigerians with Type 1 or Type 2 diabetes mellitus. Design:- Case control study. Setting:- University College Hospital, Ibadan, Oyo State, Nigeria. Subjects:- Forty-two subjects with diabetic mellitus (17 Type 1 D. M. and 25 Type 2 D. M.) and 21 apparently healthy control subjects. Intervention:- Serum level of CICs was measured by polyethylene glycol precipitation method while single radial immunodiffusion method was used to measure serum levels of immunoglobulins and complement components. Results:- Only CICs were significantly higher in Type 1 diabetic subjects compared with the controls whereas CICs C3c, C4 and IgM were significantly increased in Type 2 diabetic subjects compared with the controls. The levels of CICs, C3c and IgM were significantly elevated in Type 2 diabetics compared with Type 1 diabetics. Conclusion:- CIC concentrations may serve as a useful index of depressed host defences usually associated with diabetics mellitus and that humoral immunity is deranged more in Type 2 diabetics compared with Type 1 diabetics. Probably as a result of hyperinsulinaemia associated with insulin resistance. Key Words: Immune complexes, Immuno-globulins, Complement factor, Diabetic mellitus, Deranged. Resume Objectif:- Evaluer le taux du serum de la circulation des types d'immunoglobine complexe immune (IgG, IgA, et IgM) et composant du complement (C3c, C4 et Bfacteur) chez les Nigerians avec type 1 or type 2 diabetes mellitus. Plan:- Une etude de cas d'un controle. Cadre:- College hospitalier universitaire, Ibadan, Etat d'Oyo, Nigeria. Sujets:- Quarante deux sujets atteints du diabetes mellitus (17 type 1 D. M. et 25 Type 2 D. M.) et 21 apparemment en tres bonne sante sujets de controle. Intervention:- Taux de serum de CICs etait mesure par la methode de la precipitation glycol polyethylene tandis que la methode d'immunodiffusion seul radial etait utilisee pour mesurer le taux de serum de taux de I'immunoglobuline et composants du complement. Resultats:- CICs seulement etait remarquablement eleve chez les sujets diabetiques Type 1 par rapport au controle tandis que CISs C3c, C4 et IgM etaient remarquablement eleves chez des sujets diabetiques Type 2 par rapport aux controles. Les taux de CICs, C3c et IgM etaient remarquablement eleves chez les diabetique type 2 par rapport aux diabetiques Type 1. Conclusion:- La concentration de CIC pourrait servir comme un indice tres utile comme des defences pour des hotes deprimes le plus souvent, associe avec diabetiques mellitus et que l'immunite a mediation humorale (par voie sanguine), est de plus derangee chez les diabetiques Type 2 par rapport aux diabetiques type 1. Peut-etre attributable a l'hyperinsulinanemie associee avec la resistance d'insulin. West African Journal of Medicine Vol.23(3) 2004: 253-255 |
| Databáze: | OpenAIRE |
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