Biocompatible Films with Tailored Spectral Response for Prevention of DNA Damage in Skin Cells

Autor: Mauricio E. Calvo, Rebeca Núñez-Lozano, Belén Pimentel, Hernán Míguez, Guillermo de la Cueva-Méndez, José R. Castro-Smirnov
Rok vydání: 2015
Předmět:
Zdroj: Advanced Healthcare Materials
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 2192-2659
2192-2640
DOI: 10.1002/adhm.201500223
Popis: Protection from solar radiation is commonly achieved through the use of UV organic absorbers, such as benzophenones or benzotriazoles, often combined with inorganic materials such as TiO2 or ZnO2, supplied in the form of submicron size particles.[1] These compounds are usually dispersed in lotions or films,[2] the latter being typically made of polymers or inorganic glasses.[3,4] Lotions are mainly employed for skin protection, whilst solid state dispersions and coatings are typically used to improve the durability of plastics, whose mechanical stability is compromised by chain scissions, chain crosslinks and chain oxidations induced by UV absorption. Accordingly, these types of films are used in the fabrication of food packaging, to preserve containers and their edible contents from UV-induced damage, and also of glasses, to impede that UV rays reach, and harm, the eye. Solid state approaches to UV shielding might also find relevant applications in the field of skin protection, as they could be integrated in all sorts of screens or epidermal patches. However, a drawback of films like the above is that UV absorption induces the generation of free radicals, which not only reduce the mechanical stability of the polymer matrix progressively but also are toxic to cells.[5–7] Overcoming the problems associated to this inappropriate stability and biocompatibility may be possible using UV-reflecting films, which have been proposed recently as an alternative to traditional UV-absorbing-based materials.[8] There, the traditionally employed UV-absorption mechanism is substituted by radiation blockage, achieved as a result of the strong reflectance that arises from optical interference effects. This optical shielding has therefore a structural origin, rather than compositional, and has the advantage of preventing the undesired effects that highly reactive chemical species produced upon UV absorption have on the films themselves and on the tissues that they intend to protect. Besides all this, an appealing feature of UV-reflecting films is that their optical response can be tailored to measure, so that they block very efficiently any predetermined wavelength range.
Databáze: OpenAIRE
Externí odkaz: