Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark)
| Autor: | Ann Olsson, Niels E. Skakkebæk, Charlotte Le Cornet, Béatrice Fervers, Susanne Oksbjerg Dalton, Kayo Togawa, Johnni Hansen, Maria Feychting, Joachim Schüz, Eero Pukkala |
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| Přispěvatelé: | University of Tampere |
| Rok vydání: | 2018 |
| Předmět: |
Male
Denmark statistics denmark 0302 clinical medicine Paternal Exposure/adverse effects perinatal risk factor Medicine nord-test Registries education.field_of_study 030219 obstetrics & reproductive medicine Neoplasms Germ Cell and Embryonal Solvents/toxicity 030220 oncology & carcinogenesis Paternal Exposure language danish supplementary pension fund Metals Heavy/toxicity Public aspects of medicine RA1-1270 Adult Adolescent Testicular Neoplasms/epidemiology Population prenatal risk factor solvent Nuclear Family Danish 03 medical and health sciences Testicular Neoplasms Syöpätaudit - Cancers Metals Heavy Occupational Exposure cancer toluene Humans education Nuclear family Birth Year nocca-jem chromium vi business.industry danish cancer registry Public Health Environmental and Occupational Health Case-control study Odds ratio heavy metal Neoplasms Germ Cell and Embryonal/epidemiology Denmark/epidemiology Confidence interval language.human_language parental occupational exposure case−control study Solvents testicular germ cell tumor business Demography |
| Zdroj: | Olsson, A, Togawa, K, Schüz, J, Le Cornet, C, Fervers, B, Oksbjerg Dalton, S, Pukkala, E, Maria Feychting, M F, Skakkebæk, N E & Hansen, J 2018, ' Parental occupational exposure to solvents and heavy metals and risk of developing testicular germ cell tumors in sons (NORD-TEST Denmark) ', Scandinavian Journal of Work, Environment & Health, vol. 44, no. 6, pp. 658-669 . https://doi.org/10.5271/sjweh.3732 Scandinavian Journal of Work, Environment & Health, Vol 44, Iss 6, Pp 658-669 (2018) |
| ISSN: | 1795-990X 0355-3140 |
| DOI: | 10.5271/sjweh.3732 |
| Popis: | Objective The present study aims to assess if parental occupational exposure to solvents or heavy metals is associated with risk of testicular germ cell tumors (TGCT) in sons in Denmark. Methods The NORD-TEST Denmark included 3421 cases diagnosed with TGCT at ages 14-49 years in Denmark between 1981 and 2014. Controls (N=14 024) selected from the central population registry were matched to cases on birth year. The Danish Supplementary Pension Fund provided parental occupational information. A job-exposure matrix was used to assign exposures, and conditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results The overall analyses showed no significant associations except for paternal exposure to a sub-group of "heavy metal(s) and solvent(s)" (OR 1.50, 95% CI 1.01-2.24). Most fathers in this category had worked in wood related jobs and were assigned exposure to chromium VI and toluene. Other sub-group analyses suggested that maternal exposure to aromatic hydrocarbon were associated with TGCT risk, in sons born in 1970-1979, and to heavy metals (chromium, iron and nickel) in sons born in 1980-1998. Conclusion NORD-TEST Denmark provides no strong support for an association between parental exposures to solvents or heavy metals and TGCT in sons, and only weak support for an association between paternal exposure to chromium and toluene and TGCT risk in sons. |
| Databáze: | OpenAIRE |
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