'In-bore' MRI-guided Prostate Biopsy Using an Endorectal Nonmagnetic Device: A Prospective Study of 70 Consecutive Patients
| Autor: | Riccardo Schiavina, Valerio Vagnoni, A. Salvaggio, Francesco Chessa, Caterina Gaudiano, Marco Giampaoli, Daniele D'Agostino, Hussam Dababneh, Giuseppe Martorana, Daniele Romagnoli, Eugenio Brunocilla, Marco Borghesi, Giacomo Saraceni, Cristian Vincenzo Pultrone, Angelo Porreca, Lorenzo Bianchi, Mario Vigo, Gaetano La Manna |
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| Přispěvatelé: | Schiavina, R, Vagnoni, V, D'Agostino, D, Borghesi, M, Salvaggio, A, Giampaoli, M, Pultrone, Cv, Saraceni, G, Gaudiano, C, Vigo, M, Bianchi, L, Dababneh, H, La Manna, G, Chessa, F, Romagnoli, D, Martorana, G, Brunocilla, E, Porreca, A |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Prostate biopsy Urology 030232 urology & nephrology Magnetic Resonance Imaging Interventional Image-guided biopsy 03 medical and health sciences Prostate cancer 0302 clinical medicine Magnetic resonance imaging Interquartile range Biopsy medicine Humans Prospective Studies Aged medicine.diagnostic_test Index Lesion business.industry Hazard ratio Prostatic Neoplasms Clinically significant disease Detection rate Middle Aged Prostate-Specific Antigen medicine.disease Oncology 030220 oncology & carcinogenesis Radiology Neoplasm Grading business Image-Guided Biopsy |
| Popis: | Introduction We investigated the diagnostic performance of in-bore endorectal magnetic resonance imaging-guided biopsy (MRI-GB) with a 1.5-T MRI scanner using a 32-channel coil in patients with suspected prostate cancer (PCa). Patients and Methods Seventy patients with ≥ 1 suspicious area found on the preliminary multiparametric MRI scan were enrolled. The index lesion was defined as the lesion with the greatest Prostate Imaging Reporting and Data System, version 2 (PIRADS-v2), score. MRI-GBs were performed with a nonmagnetic biopsy device, needle guide, and titanium double-shoot biopsy gun with dedicated software for needle tracking. Clinically significant PCa was defined as the presence of Gleason score ≥ 7 in the biopsy specimen. Results Seventy index lesions were scheduled for MRI-GB. The median PIRADS-v2 score and the median number of cores per patient was 4 of 5 (interquartile range, 3-5) and 2 (interquartile range, 1-3), respectively. The PCa detection rate was 45.7%. Of the 70 patients, 24 (75%) had clinically significant PCa, with a significant correlation between the PIRADS-v2 score and the Gleason score in the MRI-GB cores ( r = 0.839; 95% confidence interval, 0.535-0.951; P = .003). According to the PIRADs-v2 scheme, the proportion of PCa in the central and anterior regions of the gland was greater in the entire population and in the subgroup of patients with a history of negative transrectal ultrasound-guided biopsy findings ( P ≤ .01 for all). On multivariate analysis, a PIRADS-v2 score of 5 of 5 correlated significantly with the likelihood of PCa at biopsy (hazard ratio, 4.69; 95% confidence interval, 0.92-23.74; P = .04). No major complications were recorded. Conclusion MRI-GB has a high detection rate for PCa, especially for lesions located in the central and anterior regions of the prostate. |
| Databáze: | OpenAIRE |
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