Correlation between Circulating Soluble ICAM-1 and Prednisolone-induced Amelioration of Ulcerative Colitis
| Autor: | Ben Vainer, O. Haagen Nielsen |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Prednisolone medicine.medical_treatment Statistics as Topic Intercellular Adhesion Molecule-1 Anti-Inflammatory Agents Administration Oral Severity of Illness Index Gastroenterology 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine medicine Humans Mesalamine Glucocorticoids Aged Chemotherapy ICAM-1 Cell adhesion molecule business.industry Middle Aged medicine.disease Ulcerative colitis Treatment Outcome Endocrinology Solubility 030220 oncology & carcinogenesis Corticosteroid Colitis Ulcerative Female 030211 gastroenterology & hepatology business Biomarkers medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 38:283-287 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/00365520310000609a |
| Popis: | A soluble form of intercellular adhesion molecule-1 (sICAM-1) shed from endothelial cells is present in the circulation. Whether the circulating molecules represent passive turnover of surface ICAM-1 or may have some active functions in the inflammatory process is unknown. Glucocorticoids (e.g. prednisolone) are cornerstones in the treatment of acute exacerbations of ulcerative colitis (UC), and influence of the leucocyte/endothelial interaction appears to be part of their mode of action. The aim of the present study was therefore to evaluate the ICAM-1-shedding through measurements of sICAM-1 concentrations during prednisolone treatment of UC patients.Prednisolone (40 mg) was prescribed to 15 patients with severe disease activity. At inclusion, and after 2 weeks of treatment, plasma sICAM-1 levels were measured using the ELISA technique.The concentrations of sICAM-1 were significantly decreased during treatment from median 256.2 (ng/ml) (interquartile range 239.7-321.0 ng/ml) to 220.4 ng/ml (196.0-276.3 ng/ml) (P0.01). This reduction correlated with a decrease in disease activity (r(s) = 0.8; P0.003).sICAM-1 seems to be a poor diagnostic tool, but since plasma sICAM-1 concentrations decreased during the treatment period, it might prove to be applicable as an activity marker in the individual patient. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|