Subclinical hypothyroidism does not influence the metabolic and hormonal profile of women with PCOS
| Autor: | Erifili Hatziagelaki, Vasilios Pergialiotis, Nikolaos Papantoniou, Ioannis Salloum, Eftihios Trakakis, Periklis Panagopoulos |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Anovulation 03 medical and health sciences Follicle-stimulating hormone Young Adult 0302 clinical medicine Endocrinology Hypothyroidism Internal medicine medicine Humans Metabolomics Body Weights and Measures Prospective Studies Child Molecular Biology hirsutism Subclinical infection Glycemic Ultrasonography 030219 obstetrics & reproductive medicine business.industry Polycystic ovary syndrome (PCOS) Case-control study General Medicine medicine.disease Polycystic ovary Lipids Hormones Case-Control Studies Metabolome Female business Energy Metabolism Biomarkers Polycystic Ovary Syndrome |
| Zdroj: | Hormone molecular biology and clinical investigation. 31(3) |
| ISSN: | 1868-1891 |
| Popis: | BackgroundSubclinical hypothyroidism (SCH) is present in 5%–10% of polycystic ovary syndrome (PCOS) patients. To date, its impact on the metabolic and hormonal profile of those women remains controversial. The purpose of our study is to evaluate the impact of SCH on the glycemic, lipid and hormonal profile of PCOS patients.Materials and methodsWe conducted a prospective case control study of patients that attended the Department of Gynecological Endocrinology of our hospital.ResultsOverall, 280 women with PCOS were enrolled during a time period of 7 years (2009–2015). Twenty-one patients (7.5%) suffered from SCH. The anthropometric characteristics were comparable among women with PCOS and those with SCH + PCOS. The prevalence of acne, hirsutism and anovulation did not differ. Significant differences were observed in the 2-h oral glucose tolerance test (OGTT) (p = 0.003 for glucose and p = 0.046 for insulin). The QUICKI, Matsuda and homeostatic model assessment-insulin resistance (HOMA-IR) indices where, however, similar. No difference in serum lipids was observed. Slightly elevated levels of follicle stimulating hormone (FSH) and testosterone were noted. The remaining hormonal parameters remained similar among groups. Similarly, the ovarian volume and the endometrial thickness did not differ.ConclusionsThe impact of SCH on the metabolic and hormonal profile of PCOS patients seems to be negligible. Future studies are needed in the field and their conduct in a multi-institutional basis seems to be required, given the small prevalence of SCH among women with PCOS. |
| Databáze: | OpenAIRE |
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